The Potential of Exosomes Derived from Chronic Myelogenous Leukaemia Cells as a Biomarker
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Ka-Won | - |
dc.contributor.author | Jung, Jik-Han | - |
dc.contributor.author | Hur, Woojune | - |
dc.contributor.author | Park, Jaena | - |
dc.contributor.author | Shin, Hyunku | - |
dc.contributor.author | Choi, Byeonghyeon | - |
dc.contributor.author | Jeong, Hyesun | - |
dc.contributor.author | Kim, Dae Sik | - |
dc.contributor.author | Yu, Eun Sang | - |
dc.contributor.author | Lee, Se Ryeon | - |
dc.contributor.author | Sung, Hwa Jung | - |
dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Kim, Hyun Koo | - |
dc.contributor.author | Hong, Sunghoi | - |
dc.contributor.author | Park, Ji-Ho | - |
dc.contributor.author | Choi, Yeonho | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.date.accessioned | 2021-09-02T09:15:17Z | - |
dc.date.available | 2021-09-02T09:15:17Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74470 | - |
dc.description.abstract | Background/Aim: Exosomes, derived from chronic myelogenous leukaemia (CML) cells, can be used as biomarkers and new targets for the detection of the BCR-ABL transcript. This study aimed to identify these possibilities. Materials and Methods: Human CML cell line-derived exosomes and CML-patients-derived exosomes were isolated with a size-exclusion chromatography column and ExoQuick (TM) exosome precipitation solution, respectively. Isolated exosomes were analysed by nested PCR to detect the BCR-ABL transcript. Results: Exosomes derived from the two human CML cell lines yielded a 250-bp band. RNA sequence analysis revealed 99% sequence homology with the partial mRNA for the human BCR-ABL chimeric protein. This similar to 250-bp band was also observed in the exosomes derived from patients with CML. However, only patients at the blast and accelerated phases showed the exosomal BCR-ABL transcript. Conclusion: CML-derived exosomes could act as novel targets for the detection of the BCR-ABL transcript. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.subject | CHRONIC MYELOID-LEUKEMIA | - |
dc.subject | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject | BCR-ABL TRANSCRIPTS | - |
dc.subject | BONE-MARROW | - |
dc.subject | EXTRACELLULAR VESICLES | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | CANCER | - |
dc.subject | RECOMMENDATIONS | - |
dc.subject | INHIBITORS | - |
dc.subject | DISEASE | - |
dc.title | The Potential of Exosomes Derived from Chronic Myelogenous Leukaemia Cells as a Biomarker | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sik | - |
dc.contributor.affiliatedAuthor | Lee, Se Ryeon | - |
dc.contributor.affiliatedAuthor | Sung, Hwa Jung | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Koo | - |
dc.contributor.affiliatedAuthor | Hong, Sunghoi | - |
dc.contributor.affiliatedAuthor | Choi, Yeonho | - |
dc.contributor.affiliatedAuthor | Park, Yong | - |
dc.contributor.affiliatedAuthor | Kim, Byung Soo | - |
dc.identifier.doi | 10.21873/anticanres.12679 | - |
dc.identifier.scopusid | 2-s2.0-85049772803 | - |
dc.identifier.wosid | 000449943500018 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.38, no.7, pp.3935 - 3942 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 38 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3935 | - |
dc.citation.endPage | 3942 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CHRONIC MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject.keywordPlus | BCR-ABL TRANSCRIPTS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Chronic myelogenous leukaemia | - |
dc.subject.keywordAuthor | exosome | - |
dc.subject.keywordAuthor | BCR-ABL | - |
dc.subject.keywordAuthor | biomarker | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.