Long-Term Clinical Outcomes of Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer: A Prospective Multicenter Cohort Study
- Authors
- Kim, Sang Gyun; Park, Chan Mi; Lee, Na Rae; Kim, Jiyoung; Lyu, Da Hyun; Park, Seung-Hee; Choi, Il Ju; Lee, Wan Sik; Park, Seun Ja; Kim, Jae Jun; Ki, Ji Hyun; Lim, Chul-Hyun; Cho, Joo Young; Kim, Gwang Ha; Lee, Yong Chan; Jung, Hwoon-Yong; Lee, Jun Haeng; Chun, Hoon Jai; Seol, Sang-Yong
- Issue Date
- 7월-2018
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Survival; Endoscopic mucosal dissection; Stomach neoplasms
- Citation
- GUT AND LIVER, v.12, no.4, pp.402 - 410
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- GUT AND LIVER
- Volume
- 12
- Number
- 4
- Start Page
- 402
- End Page
- 410
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/74807
- DOI
- 10.5009/gnl17414
- ISSN
- 1976-2283
- Abstract
- Background/Aims: Endoscopic submucosa I dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during-follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.
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