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Roles of 14-3-3 beta and gamma in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis

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dc.contributor.authorHwang, Yunhee-
dc.contributor.authorAn, Hyoung-Tae-
dc.contributor.authorKang, Minsoo-
dc.contributor.authorKo, Jesang-
dc.date.accessioned2021-09-02T10:03:56Z-
dc.date.available2021-09-02T10:03:56Z-
dc.date.created2021-06-16-
dc.date.issued2018-06-27-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/74890-
dc.description.abstractThe glucocorticoid receptor (GR) is a ligand-dependent transcription factor that mediates the effects of glucocorticoids, and plays a crucial role in cell growth, development, inflammation, and gluconeogenesis. The 14-3-3 proteins bind to target proteins via phosphorylation, and influence many cellular events by altering their subcellular localization or by acting as chaperones. However, the mechanisms by which 14-3-3 proteins regulate GR transactivation and their involvement in gluconeogenesis remain uncharacterized. We found that 14-3-3 beta and gamma increased GR transcriptional activity and the promoter activities of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase in the presence of glucocorticoids. Inhibition of the endogenous 14-3-3 beta and gamma decreased dexamethasone- and cAMP-stimulated PEPCK expression. Further, both 14-3-3 beta and gamma increased glucose production in response to glucocorticoids. Our findings suggest that 14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis. (C) 2018 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectPHOSPHOENOLPYRUVATE CARBOXYKINASE-
dc.subjectTRANSACTIVATION DOMAIN-
dc.subjectPROTEINS-
dc.subjectGENE-
dc.subjectMODULATION-
dc.subjectEXPRESSION-
dc.subjectELEMENTS-
dc.titleRoles of 14-3-3 beta and gamma in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis-
dc.typeArticle-
dc.contributor.affiliatedAuthorKo, Jesang-
dc.identifier.doi10.1016/j.bbrc.2018.05.077-
dc.identifier.scopusid2-s2.0-85047190667-
dc.identifier.wosid000436057500029-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.501, no.3, pp.800 - 806-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume501-
dc.citation.number3-
dc.citation.startPage800-
dc.citation.endPage806-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusPHOSPHOENOLPYRUVATE CARBOXYKINASE-
dc.subject.keywordPlusTRANSACTIVATION DOMAIN-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusMODULATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusELEMENTS-
dc.subject.keywordAuthor14-3-3-
dc.subject.keywordAuthorGlucocorticoid receptor-
dc.subject.keywordAuthorPhosphoenolpyruvate carboxykinase-
dc.subject.keywordAuthorGlucose-6-phosphatase-
dc.subject.keywordAuthorGluconeogenesis-
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