Roles of 14-3-3 beta and gamma in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis
DC Field | Value | Language |
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dc.contributor.author | Hwang, Yunhee | - |
dc.contributor.author | An, Hyoung-Tae | - |
dc.contributor.author | Kang, Minsoo | - |
dc.contributor.author | Ko, Jesang | - |
dc.date.accessioned | 2021-09-02T10:03:56Z | - |
dc.date.available | 2021-09-02T10:03:56Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06-27 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74890 | - |
dc.description.abstract | The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that mediates the effects of glucocorticoids, and plays a crucial role in cell growth, development, inflammation, and gluconeogenesis. The 14-3-3 proteins bind to target proteins via phosphorylation, and influence many cellular events by altering their subcellular localization or by acting as chaperones. However, the mechanisms by which 14-3-3 proteins regulate GR transactivation and their involvement in gluconeogenesis remain uncharacterized. We found that 14-3-3 beta and gamma increased GR transcriptional activity and the promoter activities of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase in the presence of glucocorticoids. Inhibition of the endogenous 14-3-3 beta and gamma decreased dexamethasone- and cAMP-stimulated PEPCK expression. Further, both 14-3-3 beta and gamma increased glucose production in response to glucocorticoids. Our findings suggest that 14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | PHOSPHOENOLPYRUVATE CARBOXYKINASE | - |
dc.subject | TRANSACTIVATION DOMAIN | - |
dc.subject | PROTEINS | - |
dc.subject | GENE | - |
dc.subject | MODULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | ELEMENTS | - |
dc.title | Roles of 14-3-3 beta and gamma in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.05.077 | - |
dc.identifier.scopusid | 2-s2.0-85047190667 | - |
dc.identifier.wosid | 000436057500029 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.501, no.3, pp.800 - 806 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 501 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 800 | - |
dc.citation.endPage | 806 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | PHOSPHOENOLPYRUVATE CARBOXYKINASE | - |
dc.subject.keywordPlus | TRANSACTIVATION DOMAIN | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ELEMENTS | - |
dc.subject.keywordAuthor | 14-3-3 | - |
dc.subject.keywordAuthor | Glucocorticoid receptor | - |
dc.subject.keywordAuthor | Phosphoenolpyruvate carboxykinase | - |
dc.subject.keywordAuthor | Glucose-6-phosphatase | - |
dc.subject.keywordAuthor | Gluconeogenesis | - |
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