Impact of Heart Rate Reduction with Maximal Tolerable Dose of Bisoprolol on Left Ventricular Reverse Remodeling
DC Field | Value | Language |
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dc.contributor.author | Choi, Suk-Won | - |
dc.contributor.author | Han, Seongwoo | - |
dc.contributor.author | Shim, Wan Joo | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Yoo, Byung-Su | - |
dc.contributor.author | Hwang, Kyung-Kuk | - |
dc.contributor.author | Jeon, Hui Kyung | - |
dc.contributor.author | Shin, Mi-Seung | - |
dc.contributor.author | Ryu, Kyu-Hyung | - |
dc.date.accessioned | 2021-09-02T10:06:28Z | - |
dc.date.available | 2021-09-02T10:06:28Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06-18 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74910 | - |
dc.description.abstract | Background: We aimed to evaluate effect of heart rate (HR) reduction on left ventricular reverse remodeling (LVRR) in Korean patients with heart failure with reduced ejection fraction (HFrEF). Methods: Ambulatory patients with HFrEF, who had paired echocardiograms, N-terminal prohormone brain natriuretic peptide (NT-proBNP), and global assessment score (GAS) at baseline and 6-month (n = 157), were followed up on preset treatment schedule with bisoprolol. Results: The LVRR occurred in 49 patients (32%) at 6-month. In multivariable analysis, independent predictors associated with LVRR were use of anti-aldosterone agent (odds ratio [OR], 4.18; 95% confidence interval [CI], 1.80-9.71), young age (OR, 0.96; 95% CI, 0.92-0.99), high baseline HR (OR, 3.76; 95% CI, 1.40-10.10), and favorable baseline GAS (OR, 1.73; 95% CI, 1.06-2.81). Beneficial effect of bisoprolol, in terms of LVRR, NT-proBNP, and GAS, was remarkable in the high HR group (baseline HR >= 75 beats per minute [bpm]), which showed a large HR reduction. Conclusion: High baseline HR (>= 75 bpm) showed an association with LVRR and improvement of NT-proBNP and GAS in patients with HFrEF. This seems to be due to a large HR reduction after treatments with bisoprolol. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | BRAIN NATRIURETIC PEPTIDE | - |
dc.subject | CORONARY-ARTERY-DISEASE | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | RISK-FACTOR | - |
dc.subject | TASK-FORCE | - |
dc.subject | FAILURE | - |
dc.subject | CARVEDILOL | - |
dc.subject | ASSOCIATION | - |
dc.subject | TRIAL | - |
dc.title | Impact of Heart Rate Reduction with Maximal Tolerable Dose of Bisoprolol on Left Ventricular Reverse Remodeling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Wan Joo | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e171 | - |
dc.identifier.scopusid | 2-s2.0-85048678238 | - |
dc.identifier.wosid | 000435636500001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.25 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 25 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002353953 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | BRAIN NATRIURETIC PEPTIDE | - |
dc.subject.keywordPlus | CORONARY-ARTERY-DISEASE | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | TASK-FORCE | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | CARVEDILOL | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | Heart Failure | - |
dc.subject.keywordAuthor | Left Ventricular Reverse Remodeling | - |
dc.subject.keywordAuthor | Beta Blocker | - |
dc.subject.keywordAuthor | Heart Rate | - |
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