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Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

Authors
Yun, Ki WookChoi, Eun HwaLee, Hoan JongKang, Jin HanKim, Kyung-HyoKim, Dong SooKim, Yae-JeanEun, Byung WookOh, Sung HeeCho, Hye-KyungHong, Young JinKim, Kwang NamKim, Nam HeeKim, Yun-KyungLee, HyunjuLee, TaekjinKim, Hwang MinCho, Eun YoungKim, Chun SooPark, Su EunOh, Chi EunJo, Dae SunChoi, Young YounLee, Jina
Issue Date
8-6월-2018
Publisher
BIOMED CENTRAL LTD
Keywords
Invasive pneumococcal diseases; Pneumococcal conjugate vaccine; Multilocus sequence typing; Children
Citation
BMC INFECTIOUS DISEASES, v.18
Indexed
SCIE
SCOPUS
Journal Title
BMC INFECTIOUS DISEASES
Volume
18
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/74948
DOI
10.1186/s12879-018-3177-7
ISSN
1471-2334
Abstract
Background: Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea. Methods: A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995-2003; n = 70), post-PCV7 (2004-2010; n = 142), and post-PCV13 (2011-2013; n = 73) periods. Results: Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%. Conclusion: The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs.
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