PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Seung-Won | - |
dc.contributor.author | Park, Han-Hee | - |
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Chung, Jee Min | - |
dc.contributor.author | Noh, Hyun-Jin | - |
dc.contributor.author | Kim, Sue Kyung | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Lee, Chang-Woo | - |
dc.contributor.author | Morgan, Michael J. | - |
dc.contributor.author | Kang, Ho Chul | - |
dc.contributor.author | Kim, You-Sun | - |
dc.date.accessioned | 2021-09-02T10:20:12Z | - |
dc.date.available | 2021-09-02T10:20:12Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06-07 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74956 | - |
dc.description.abstract | Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is a central protein in necroptosis, but post-translational processes that regulate RIP3 activity and stability remain poorly understood. Here, we identify pellino E3 ubiquitin protein ligase 1 (PELI1) as an E3 ligase that targets RIP3 for proteasome-dependent degradation. Phosphorylation of RIP3 on T182 leads to interaction with the forkhead-associated (FHA) domain of PELI1 and PELI1-mediated K48-linked polyubiquitylation of RIP3 on K363. This same phosphorylation event is also important for RIP3 kinase activity; thus, PELI1 preferentially targets kinase-active RIP3 for degradation. PELI1-mediated RIP3 degradation effectively prevents cell death triggered by RIP3 hyperactivation. Importantly, upregulated RIP3 expression in keratinocytes from toxic epidermal necrolysis (TEN) patients is correlated with low expression of PELI1, suggesting that loss of PELI1 may play a role in the pathogenesis of TEN. We propose that PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | DOMAIN-LIKE PROTEIN | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | PROGRAMMED NECROSIS | - |
dc.subject | FHA DOMAIN | - |
dc.subject | PELLINO PROTEINS | - |
dc.subject | NECROPTOSIS | - |
dc.subject | CELLS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | UBIQUITINATION | - |
dc.subject | POLYUBIQUITINATION | - |
dc.title | PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.identifier.doi | 10.1016/j.molcel.2018.05.016 | - |
dc.identifier.scopusid | 2-s2.0-85047728059 | - |
dc.identifier.wosid | 000434791400017 | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.70, no.5, pp.920 - + | - |
dc.relation.isPartOf | MOLECULAR CELL | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 70 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 920 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DOMAIN-LIKE PROTEIN | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | PROGRAMMED NECROSIS | - |
dc.subject.keywordPlus | FHA DOMAIN | - |
dc.subject.keywordPlus | PELLINO PROTEINS | - |
dc.subject.keywordPlus | NECROPTOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | UBIQUITINATION | - |
dc.subject.keywordPlus | POLYUBIQUITINATION | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | FHA domain | - |
dc.subject.keywordAuthor | kinase | - |
dc.subject.keywordAuthor | PELI1 | - |
dc.subject.keywordAuthor | proteasome | - |
dc.subject.keywordAuthor | RIP3 | - |
dc.subject.keywordAuthor | ubiquitylation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.