Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae
- Authors
- Kwon, Jaeyoung; Lee, Hyaemin; Seo, Young Hye; Yun, Jieun; Lee, Jun; Kwon, Hak Cheol; Guo, Yuanqiang; Kang, Jong Soon; Kim, Jae-Jin; Lee, Dongho
- Issue Date
- 6월-2018
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.81, no.6, pp.1444 - 1450
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 81
- Number
- 6
- Start Page
- 1444
- End Page
- 1450
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75036
- DOI
- 10.1021/acs.jnatprod.8b00175
- ISSN
- 0163-3864
- Abstract
- A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 mu M.
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- Appears in
Collections - College of Life Sciences and Biotechnology > Division of Environmental Science and Ecological Engineering > 1. Journal Articles
- Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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