Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma: a large, multicenter cohort analysis
DC Field | Value | Language |
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dc.contributor.author | Son, Sumin | - |
dc.contributor.author | Hwang, Eu-Chang | - |
dc.contributor.author | Jung, Scung-Il | - |
dc.contributor.author | Kwon, Dong-Deuk | - |
dc.contributor.author | Choi, Seock-Hwan | - |
dc.contributor.author | Kwon, Tae-Gyun | - |
dc.contributor.author | Noh, Joon-Hwa | - |
dc.contributor.author | Kim, Myung-Ki | - |
dc.contributor.author | Seo, Ill-Young | - |
dc.contributor.author | Kim, Chul-Sung | - |
dc.contributor.author | Kang, Sung-Gu | - |
dc.contributor.author | Cheon, Jun | - |
dc.contributor.author | Ha, Hong-Koo | - |
dc.contributor.author | Jeong, Chang-Wook | - |
dc.contributor.author | Ku, Ja-Hyeon | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Kim, Hyeon-Hoe | - |
dc.date.accessioned | 2021-09-02T10:37:21Z | - |
dc.date.available | 2021-09-02T10:37:21Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0393-2249 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75038 | - |
dc.description.abstract | BACKGROUND: The aim of this study was to investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated. Univariable and multivariable analysis was performed using the Cox proportional hazards regression model. Cut-off values for NLR and PLR were calculated using a receiver operating characteristic curve. RESULTS: The median follow-up period was 39.1 (interquartile range: 18.3-63.8) months. Univariable analysis revealed that GPS, mGPS, PLR, and NLR (all, P=0.001) were significantly associated with both recurrence-free survival (RFS) and cancer-specific survival (CSS). Multivariable analysts revealed that GPS (P=0.001), PLR (hazards ratio [HR] =1.32; 95% CI: 1.08-1.62, P=0.007 and HR =1.87; 95% CI: 1.21-2.92, P=0.005), NLR (HR =1.38; 95% CI: 1.12-1.69, P=0.003 and HR =1.70; 95% CI: 1.10-2.62, P=0.017) were significantly associated with RFS and CSS. CONCLUSIONS: Our results suggest that preoperative systemic inflammation markers such as GPS, PLR, and NLR are independent prognostic factors in patients with UTUC after surgery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDIZIONI MINERVA MEDICA | - |
dc.subject | NEUTROPHIL-LYMPHOCYTE RATIO | - |
dc.subject | PERFORMANCE STATUS ECOG | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | SCORE GPS | - |
dc.subject | SURVIVAL | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | VALIDATION | - |
dc.title | Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma: a large, multicenter cohort analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Sung-Gu | - |
dc.contributor.affiliatedAuthor | Cheon, Jun | - |
dc.identifier.doi | 10.23736/S0393-2249.18.02914-4 | - |
dc.identifier.scopusid | 2-s2.0-85049991828 | - |
dc.identifier.wosid | 000445302200007 | - |
dc.identifier.bibliographicCitation | MINERVA UROLOGICA E NEFROLOGICA, v.70, no.3, pp.300 - 309 | - |
dc.relation.isPartOf | MINERVA UROLOGICA E NEFROLOGICA | - |
dc.citation.title | MINERVA UROLOGICA E NEFROLOGICA | - |
dc.citation.volume | 70 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 300 | - |
dc.citation.endPage | 309 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | NEUTROPHIL-LYMPHOCYTE RATIO | - |
dc.subject.keywordPlus | PERFORMANCE STATUS ECOG | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | SCORE GPS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Carcinoma, transitional cell | - |
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