Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics
DC Field | Value | Language |
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dc.contributor.author | Lee, Gi Young | - |
dc.contributor.author | You, Deok-gyun | - |
dc.contributor.author | Lee, Hye-Ra | - |
dc.contributor.author | Hwang, Sun Wook | - |
dc.contributor.author | Lee, C. Justin | - |
dc.contributor.author | Do Yoo, Young | - |
dc.date.accessioned | 2021-09-02T10:40:22Z | - |
dc.date.available | 2021-09-02T10:40:22Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75063 | - |
dc.description.abstract | Reactive oxygen species (ROS) modulator 1 (Romo1) is a nuclear-encoded mitochondrial inner membrane protein known to regulate mitochondrial ROS production and to act as an essential redox sensor in mitochondrial dynamics. Although its physiological roles have been studied for a decade, the biophysical mechanisms that explain these activities of Romo1 are unclear. In this study, we report that Romo1 is a unique mitochondrial ion channel that differs from currently identified eukaryotic ion channels. Romo1 is a highly conserved protein with structural features of class II viroporins, which are virus-encoded nonselective cation channels. Indeed, Romo1 forms a nonselective cation channel with its amphipathic helical transmembrane domain necessary for pore-forming activity. Notably, channel activity was specifically inhibited by Fe2+ ions, an essential transition metal ion in ROS metabolism. Using structural bioinformatics, we designed an experimental data-guided structural model of Romo1 with a rational hexameric structure. We propose that Romo1 establishes a new category of viroporin-like nonselective cation channel in eukaryotes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.subject | HEPATITIS-C-VIRUS | - |
dc.subject | PROTEIN-STRUCTURE PREDICTION | - |
dc.subject | PERMEABILITY TRANSITION | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | POTASSIUM CHANNELS | - |
dc.subject | ROS PRODUCTION | - |
dc.subject | ION CHANNELS | - |
dc.subject | SERVER | - |
dc.subject | P7 | - |
dc.subject | MEMBRANES | - |
dc.title | Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Sun Wook | - |
dc.contributor.affiliatedAuthor | Do Yoo, Young | - |
dc.identifier.doi | 10.1083/jcb.201709001 | - |
dc.identifier.scopusid | 2-s2.0-85048133052 | - |
dc.identifier.wosid | 000438077800018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.217, no.6, pp.2059 - 2071 | - |
dc.relation.isPartOf | JOURNAL OF CELL BIOLOGY | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 217 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2059 | - |
dc.citation.endPage | 2071 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | HEPATITIS-C-VIRUS | - |
dc.subject.keywordPlus | PROTEIN-STRUCTURE PREDICTION | - |
dc.subject.keywordPlus | PERMEABILITY TRANSITION | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | POTASSIUM CHANNELS | - |
dc.subject.keywordPlus | ROS PRODUCTION | - |
dc.subject.keywordPlus | ION CHANNELS | - |
dc.subject.keywordPlus | SERVER | - |
dc.subject.keywordPlus | P7 | - |
dc.subject.keywordPlus | MEMBRANES | - |
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