Effect of electronic cigarettes on human middle ear
DC Field | Value | Language |
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dc.contributor.author | Song, Jae-Jun | - |
dc.contributor.author | Go, Yoon Young | - |
dc.contributor.author | Mun, Ji Yoen | - |
dc.contributor.author | Lee, Sehee | - |
dc.contributor.author | Im, Gi Jung | - |
dc.contributor.author | Kim, Yoo Yon | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.contributor.author | Chang, Jiwon | - |
dc.date.accessioned | 2021-09-02T10:41:16Z | - |
dc.date.available | 2021-09-02T10:41:16Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0165-5876 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75071 | - |
dc.description.abstract | Objective: Electronic cigarettes (e-cigarettes) are the most commonly used electronic nicotine delivery systems and are a relatively new product designed for smoking cessation. The market scale of electronic cigarettes is growing rapidly, but the potential impact of e-cigarettes on public health has not yet been verified. In this study, we examined the effect of e-liquids on a human middle ear epithelial cell (HMEEC) line. Material and methods: The main components of e-liquids are propylene glycol, vegetable glycerin and flavoring agents with or without nicotine. We analyzed 73 bottles of e-liquids from 12 different manufacturers, evaluated the trace elements in e-liquids, and identified the cytotoxicity of e-liquids on HMEECs in the presence or absence of nicotine. Results: In the trace elements analysis, nickel, arsenic, cadmium, and lead were detected in the e-liquids. E-liquids without nicotine decreased cell viability, and the average IC50 value of total e-liquids (n = 73) was 2.48 +/- 0.93%. Among the different flavors, menthol-flavored e-liquids significantly reduced cell viability, and their average IC50 value (n = 28) was 1.85 +/- 0.80%. The average IC50 values were distinct among manufacturers and the proportion of the solvents. Conclusion: The present study provides evidence that e-cigarettes influence and reduce human middle ear cell viability even without the application of nicotine. Additionally, the cytotoxicity of e-liquids was affected by the flavoring agents. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | SMOKERS | - |
dc.subject | USERS | - |
dc.title | Effect of electronic cigarettes on human middle ear | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.contributor.affiliatedAuthor | Go, Yoon Young | - |
dc.contributor.affiliatedAuthor | Im, Gi Jung | - |
dc.identifier.doi | 10.1016/j.ijporl.2018.03.028 | - |
dc.identifier.scopusid | 2-s2.0-85044600432 | - |
dc.identifier.wosid | 000432766000014 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, v.109, pp.67 - 71 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | - |
dc.citation.volume | 109 | - |
dc.citation.startPage | 67 | - |
dc.citation.endPage | 71 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | SMOKERS | - |
dc.subject.keywordPlus | USERS | - |
dc.subject.keywordAuthor | Electronic cigarette | - |
dc.subject.keywordAuthor | Heavy metals | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Human middle ear epithelial cells | - |
dc.subject.keywordAuthor | Otitis media | - |
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