Systematic review and meta-analysis of single-dose and non-single-dose methotrexate protocols in the treatment of ectopic pregnancy
- Authors
- Yuk, Jin-Sung; Lee, Jung Hun; Park, Won I.; Ahn, Hyeong Sik; Kim, Hyun Jung
- Issue Date
- 6월-2018
- Publisher
- WILEY
- Keywords
- Ectopic pregnancy; Methotrexate; Multi-dose protocol; Single-dose protocol; Systematic review
- Citation
- INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, v.141, no.3, pp.295 - 303
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
- Volume
- 141
- Number
- 3
- Start Page
- 295
- End Page
- 303
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75399
- DOI
- 10.1002/ijgo.12473
- ISSN
- 0020-7292
- Abstract
- Background: It remains unclear which methotrexate protocol for the treatment of ectopic pregnancy has a higher success rate or a higher adverse effect rate. Objective: To compare the treatment success rates and adverse effect rates of single-dose and non-single-dose (two-dose and multi-dose) methotrexate protocols in the treatment of ectopic pregnancy. Search strategy: Various databases including Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched on July 1, 2017, using search terms including "methotrexate" and "pregnancy." Selection criteria: Randomized controlled trials comparing different methotrexate protocols for the treatment of ectopic pregnancy were included. Data collection and analysis: Relative risks (RRs) and 95% confidence intervals (CIs) were calculated to compare treatment success rates and adverse effect rates. Main results: The single-dose and non-single-dose protocols had similar success rates (RR 1.00, 95% CI 0.96-1.04; 11 trials, 1121 patients, I-2=18%). The non-single-dose protocols had a higher adverse effect rate than did the single-dose protocol (RR 0.73, 95% CI 0.59-0.91; nine trials, 934 patients, I-2=0%). Conclusions: The single-dose methotrexate protocol was the optimal protocol for the medical treatment of ectopic pregnancy.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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