Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats
DC Field | Value | Language |
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dc.contributor.author | Seo, Eunhye | - |
dc.contributor.author | Kang, Purum | - |
dc.contributor.author | Seol, Geun Hee | - |
dc.date.accessioned | 2021-09-02T11:15:42Z | - |
dc.date.available | 2021-09-02T11:15:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75424 | - |
dc.description.abstract | Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-anethole can prevent hypertension, suggesting that trans-anethole may be useful as a prophylactic antihypertensive agent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | SYSTEMATIC ANALYSIS | - |
dc.subject | EXPERIMENTAL-MODEL | - |
dc.subject | AQUEOUS EXTRACT | - |
dc.subject | SALVIA-SCLAREA | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | ESSENTIAL OIL | - |
dc.subject | RISK | - |
dc.subject | PREHYPERTENSION | - |
dc.subject | METAANALYSIS | - |
dc.title | Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seol, Geun Hee | - |
dc.identifier.doi | 10.1016/j.biopha.2018.03.081 | - |
dc.identifier.scopusid | 2-s2.0-85044101747 | - |
dc.identifier.wosid | 000432583800030 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, v.102, pp.249 - 253 | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.title | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.volume | 102 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 253 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | SYSTEMATIC ANALYSIS | - |
dc.subject.keywordPlus | EXPERIMENTAL-MODEL | - |
dc.subject.keywordPlus | AQUEOUS EXTRACT | - |
dc.subject.keywordPlus | SALVIA-SCLAREA | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | ESSENTIAL OIL | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PREHYPERTENSION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordAuthor | Trans-anethole | - |
dc.subject.keywordAuthor | Restraint | - |
dc.subject.keywordAuthor | Stress | - |
dc.subject.keywordAuthor | Nicotine | - |
dc.subject.keywordAuthor | Hypertension | - |
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