Hyperuricaemia and development of type 2 diabetes mellitus in Asian population
- Authors
- Choi, Byoung Geol; Kim, Dae Jin; Baek, Man Jong; Ryu, Yang Gi; Kim, Suhng Wook; Lee, Min Woo; Park, Ji Young; Noh, Yung-Kyun; Choi, Se Yeon; Byun, Jae Kyeong; Shim, Min Suk; Mashaly, Ahmed; Li, Hu; Park, Yoonjee; Jang, Won Young; Kim, Woohyeun; Kang, Jun Hyuk; Choi, Jah Yeon; Park, Eun Jin; Park, Sung-Hun; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Rha, Seung-Woon
- Issue Date
- 6월-2018
- Publisher
- WILEY
- Keywords
- diabetes mellitus; hyperuricaemia; risk factors; uric acid
- Citation
- CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.45, no.6, pp.499 - 506
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Volume
- 45
- Number
- 6
- Start Page
- 499
- End Page
- 506
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75449
- DOI
- 10.1111/1440-1681.12911
- ISSN
- 0305-1870
- Abstract
- Recently, meta-analysis studies reported that hyperuricaemia is associated with higher incidence of type 2 diabetes mellitus (T2DM), however, there are limited data on the Asian population. The aim of this observational study is to estimate the long-term impact of hyperuricaemia on the new-onset T2DM and cardiovascular events. This study is based on a single-centre, all-comers, and large retrospective cohort. Subjects that visited from January 2004 to February 2014 were enrolled using the electronic database of Korea University Guro Hospital. A total of 10505 patients without a history of T2DM were analyzed for uric acid, fasting glucose and haemoglobin (Hb) A1c level. Inclusion criteria included both Hb A1c <5.7% and fasting glucose level <100mg/dL without T2DM. Hyperuricaemia was defined as a uric acid level 7.0mg/dL in men, and 6.5mg/dL in women. To adjust baseline confounders, a propensity score matching (PSM) analysis was performed. The impact of hyperuricaemia on the new-onset T2DM and cardiovascular events were compared with the non-hyperuricaemia during the 5-year clinical follow-up. After PSM, baseline characteristics of both groups were balanced. In a 5-year follow-up, the hyperuricaemia itself was a strong independent predictor of the incidence of new-onset T2DM (HR, 1.78; 95% CI, 1.12 to 2.8). Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Also, hyperuricaemia is substantially implicated in cardiovascular risks and the further long-term cardiovascular events in the crude population, but it is not an independent predictor of long-term cardiovascular mortality in the matched population.
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