Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets
DC Field | Value | Language |
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dc.contributor.author | Lew, Benjamin | - |
dc.contributor.author | Kim, In-Yong | - |
dc.contributor.author | Choi, Hyungsoo | - |
dc.contributor.author | Kim, Kyekyoon (Kevin) | - |
dc.date.accessioned | 2021-09-02T11:21:43Z | - |
dc.date.available | 2021-09-02T11:21:43Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 2190-393X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75467 | - |
dc.description.abstract | The ability of glucagon-like peptide-1 analogs to enhance glucose-dependent insulin secretion and to inhibit beta cell apoptosis could be of potential benefit for islet transplantation. In this study, we investigated the effect of sustained local delivery of exenatide, a synthetic exendin-4, on the in vitro viability and function of encapsulated porcine islets. Prior to encapsulation, we fabricated exenatide-loaded poly(latic-co-glycolic acid) microspheres, and investigated their release behavior with different initial drug-loading amounts. Exenatide-loaded microspheres, exhibiting a sustained release over 21 days, were subsequently chosen and co-encapsulated with porcine islets in alginate microcapsules. During the 21-day period, the islets co-encapsulated with the exenatide-loaded microspheres exhibited improved survival and glucose-stimulated insulin secretion, compared to those without. This suggested that the intracapsular sustained delivery of exenatide via microspheres could be a promising strategy for improving survival and function of microencapsulated porcine islets for islet xenotransplantation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | PLGA MICROSPHERES | - |
dc.subject | MASS ISOLATION | - |
dc.subject | IN-VITRO | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | RELEASE | - |
dc.subject | PANCREAS | - |
dc.subject | ENCAPSULATION | - |
dc.subject | CHALLENGES | - |
dc.subject | DIGESTION | - |
dc.subject | PROGRESS | - |
dc.title | Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-Yong | - |
dc.identifier.doi | 10.1007/s13346-018-0484-x | - |
dc.identifier.scopusid | 2-s2.0-85054955086 | - |
dc.identifier.wosid | 000431508700035 | - |
dc.identifier.bibliographicCitation | DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v.8, no.3, pp.857 - 862 | - |
dc.relation.isPartOf | DRUG DELIVERY AND TRANSLATIONAL RESEARCH | - |
dc.citation.title | DRUG DELIVERY AND TRANSLATIONAL RESEARCH | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 857 | - |
dc.citation.endPage | 862 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PLGA MICROSPHERES | - |
dc.subject.keywordPlus | MASS ISOLATION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PANCREAS | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | CHALLENGES | - |
dc.subject.keywordPlus | DIGESTION | - |
dc.subject.keywordPlus | PROGRESS | - |
dc.subject.keywordAuthor | Porcine islets | - |
dc.subject.keywordAuthor | Exenatide | - |
dc.subject.keywordAuthor | Microspheres | - |
dc.subject.keywordAuthor | Microcapsules | - |
dc.subject.keywordAuthor | Islet encapsulation | - |
dc.subject.keywordAuthor | Islet xenotransplantation | - |
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