Unveiling the pathway to Z-DNA in the protein-induced B-Z transition
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sook Ho | - |
dc.contributor.author | Lim, So-Hee | - |
dc.contributor.author | Lee, Ae-Ree | - |
dc.contributor.author | Kwon, Do Hoon | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Lee, Joon-Hwa | - |
dc.contributor.author | Cho, Minhaeng | - |
dc.contributor.author | Johner, Albert | - |
dc.contributor.author | Lee, Nam-Kyung | - |
dc.contributor.author | Hong, Seok-Cheol | - |
dc.date.accessioned | 2021-09-02T11:39:01Z | - |
dc.date.available | 2021-09-02T11:39:01Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-05-04 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75572 | - |
dc.description.abstract | Left-handed Z-DNA is an extraordinary conformation of DNA, which can form by special sequences under specific biological, chemical or physical conditions. Human ADAR1, prototypic Z-DNA binding protein (ZBP), binds to Z-DNA with high affinity. Utilizing single-molecule FRET assays for Z-DNA forming sequences embedded in a long inactive DNA, we measure thermodynamic populations of ADAR1-bound DNA conformations in both GC and TG repeat sequences. Based on a statistical physics model, we determined quantitatively the affinities of ADAR1 to both Z-form and B-form of these sequences. We also reported what pathways it takes to induce the B-Z transition in those sequences. Due to the high junction energy, an intermediate B* state has to accumulate prior to the B-Z transition. Our study showing the stable B* state supports the active picture for the protein-induced B-Z transition that occurs under a physiological setting. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | Z-ALPHA DOMAIN | - |
dc.subject | HUMAN EDITING ENZYME | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | BINDING DOMAIN | - |
dc.subject | REVEALS | - |
dc.subject | COMPLEX | - |
dc.subject | NUCLEI | - |
dc.title | Unveiling the pathway to Z-DNA in the protein-induced B-Z transition | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.contributor.affiliatedAuthor | Cho, Minhaeng | - |
dc.contributor.affiliatedAuthor | Hong, Seok-Cheol | - |
dc.identifier.doi | 10.1093/nar/gky200 | - |
dc.identifier.scopusid | 2-s2.0-85051692148 | - |
dc.identifier.wosid | 000431895800034 | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.46, no.8, pp.4129 - 4137 | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 46 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 4129 | - |
dc.citation.endPage | 4137 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | Z-ALPHA DOMAIN | - |
dc.subject.keywordPlus | HUMAN EDITING ENZYME | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | BINDING DOMAIN | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | NUCLEI | - |
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