Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
DC Field | Value | Language |
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dc.contributor.author | Oh, Sang Cheul | - |
dc.contributor.author | Sohn, Bo Hwa | - |
dc.contributor.author | Cheong, Jae-Ho | - |
dc.contributor.author | Kim, Sang-Bae | - |
dc.contributor.author | Lee, Jae Eun | - |
dc.contributor.author | Park, Ki Cheong | - |
dc.contributor.author | Lee, Sang Ho | - |
dc.contributor.author | Park, Jong-Lyul | - |
dc.contributor.author | Park, Yun-Yong | - |
dc.contributor.author | Lee, Hyun-Sung | - |
dc.contributor.author | Jang, Hee-Jin | - |
dc.contributor.author | Park, Eun Sung | - |
dc.contributor.author | Kim, Sang-Cheol | - |
dc.contributor.author | Heo, Jeonghoon | - |
dc.contributor.author | Chu, In-Sun | - |
dc.contributor.author | Jang, You-Jin | - |
dc.contributor.author | Mok, Young-Jae | - |
dc.contributor.author | Jung, WonKyung | - |
dc.contributor.author | Kim, Baek-Hui | - |
dc.contributor.author | Kim, Aeree | - |
dc.contributor.author | Cho, Jae Yong | - |
dc.contributor.author | Lim, Jae Yun | - |
dc.contributor.author | Hayashi, Yuki | - |
dc.contributor.author | Song, Shumei | - |
dc.contributor.author | Elimova, Elena | - |
dc.contributor.author | Estralla, Jeannelyn S. | - |
dc.contributor.author | Lee, Jeffrey H. | - |
dc.contributor.author | Bhutani, Manoop S. | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Lee, Jeeyun | - |
dc.contributor.author | Kang, Won Ki | - |
dc.contributor.author | Kim, Sung | - |
dc.contributor.author | Noh, Sung Hoon | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Kim, Seon-Young | - |
dc.contributor.author | Ajani, Jaffer A. | - |
dc.contributor.author | Lee, Ju-Seog | - |
dc.date.accessioned | 2021-09-02T11:39:18Z | - |
dc.date.available | 2021-09-02T11:39:18Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-05-03 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75574 | - |
dc.description.abstract | Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy. Integrative analysis shows that signaling pathways driving epithelial-to-mesenchymal transition and insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) pathway are highly activated in MP subtype tumors. Importantly, MP subtype cancer cells are more sensitive to inhibition of IGF1/IGF1R pathway than EP subtype. Detailed characterization of these two subtypes could identify novel therapeutic targets and useful biomarkers for prognosis and therapy response. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | GASTROINTESTINAL STROMAL TUMORS | - |
dc.subject | COMPREHENSIVE MOLECULAR CHARACTERIZATION | - |
dc.subject | FREQUENT EPIGENETIC INACTIVATION | - |
dc.subject | GROWTH-FACTOR RECEPTOR | - |
dc.subject | PROGNOSTIC-FACTORS | - |
dc.subject | TRANSITION | - |
dc.subject | EXPRESSION | - |
dc.subject | CARCINOMA | - |
dc.subject | SUBTYPES | - |
dc.subject | INSULIN | - |
dc.title | Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Sang Cheul | - |
dc.contributor.affiliatedAuthor | Jang, You-Jin | - |
dc.contributor.affiliatedAuthor | Mok, Young-Jae | - |
dc.contributor.affiliatedAuthor | Kim, Baek-Hui | - |
dc.contributor.affiliatedAuthor | Kim, Aeree | - |
dc.identifier.doi | 10.1038/s41467-018-04179-8 | - |
dc.identifier.scopusid | 2-s2.0-85046546344 | - |
dc.identifier.wosid | 000431298400002 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | GASTROINTESTINAL STROMAL TUMORS | - |
dc.subject.keywordPlus | COMPREHENSIVE MOLECULAR CHARACTERIZATION | - |
dc.subject.keywordPlus | FREQUENT EPIGENETIC INACTIVATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.subject.keywordPlus | INSULIN | - |
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