Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization
DC Field | Value | Language |
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dc.contributor.author | Chang, Hyeyoon | - |
dc.contributor.author | Hong, Jin Hwa | - |
dc.contributor.author | Lee, Jae-Kwan | - |
dc.contributor.author | Cho, Hyun Woong | - |
dc.contributor.author | Ouh, Yung Taek | - |
dc.contributor.author | Min, Kyung Jin | - |
dc.contributor.author | So, Kyeong A. | - |
dc.date.accessioned | 2021-09-02T11:47:09Z | - |
dc.date.available | 2021-09-02T11:47:09Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 2005-0380 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75634 | - |
dc.description.abstract | Objective: Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist. The aim of this study was to determine the clinicopathologic and immunologic parameters (PD-1, PD-L1, and PD-L2) related to the persistence/recurrence of CIN after conization. Methods: Medical records of 652 patients diagnosed with CIN and underwent conization were reviewed. The associations between clinicopathologic parameters (e.g., age, parity, initial HPV load, etc.) and persistence/recurrence of CIN were analyzed. Expression of PD-1, PD-L1, and PD-L2 was assessed on 100 conization specimens by immunohistochemistry (IHC) in women matched for propensity-score (50 with persistence/recurrence and 50 without). Results: Initial HPV load (> 1,000 relative light unit) and positive margin were shown to be significantly associated with CIN persistence/recurrence (p=0.012 and p<0.001, respectively). Multivariate analysis showed that margin status was an independent predictor of persistence/ recurrence (hazard ratio=8.86; 95% confidence interval=1.67-16.81; p<0.001). On IHC analysis, none of the patients expressed PD-L1. PD-1+ T cells were observed in 25 of 100 patients. Also, PD-1+ T cells were significantly correlated with increasing grade of CIN (p=0.031). In addition, patients with persistence/recurrence had increased expression of PD-1 compared with those without (36% vs. 14%, respectively; p=0.020). Although PD-L2 expression did not differ between 2 groups, it was significantly higher in patients with high-grade CIN compared to low-grade (34.7% vs. 12%, respectively; p=0.041). Conclusion: Positive surgical margin and expression of PD-1+ T cells were associated with CIN persistence/recurrence after conization. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY | - |
dc.subject | LARGE-LOOP EXCISION | - |
dc.subject | LONG-TERM RISK | - |
dc.subject | HUMAN-PAPILLOMAVIRUS | - |
dc.subject | CLINICAL-SIGNIFICANCE | - |
dc.subject | PRE-CONIZATION | - |
dc.subject | SQUAMOUS-CELL | - |
dc.subject | FOLLOW-UP | - |
dc.subject | PERSISTENCE | - |
dc.subject | CIN | - |
dc.subject | PREDICTORS | - |
dc.title | Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jin Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Kwan | - |
dc.contributor.affiliatedAuthor | Min, Kyung Jin | - |
dc.identifier.doi | 10.3802/jgo.2018.29.e27 | - |
dc.identifier.scopusid | 2-s2.0-85047063270 | - |
dc.identifier.wosid | 000431065800002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GYNECOLOGIC ONCOLOGY, v.29, no.3 | - |
dc.relation.isPartOf | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.title | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002344023 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | LARGE-LOOP EXCISION | - |
dc.subject.keywordPlus | LONG-TERM RISK | - |
dc.subject.keywordPlus | HUMAN-PAPILLOMAVIRUS | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | PRE-CONIZATION | - |
dc.subject.keywordPlus | SQUAMOUS-CELL | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | CIN | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordAuthor | Cervical Intraepithelial Neoplasia | - |
dc.subject.keywordAuthor | Programmed Cell Death-1 | - |
dc.subject.keywordAuthor | Papillomaviridae | - |
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