PROTECTIVE EFFECTS OF PHENOLICS FROM JUJUBE (ZIZIPHUS JUJUBA) LEAF AGAINST H2O2-INDUCED OXIDATIVE STRESS IN NEURONAL PC-12 CELLS
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Jun Ho | - |
dc.contributor.author | Chi, Young Min | - |
dc.contributor.author | Jeong, Chang-Ho | - |
dc.contributor.author | Lee, Jong-Kwang | - |
dc.contributor.author | Bae, Young-Il | - |
dc.contributor.author | Hur, Sun Jin | - |
dc.date.accessioned | 2021-09-02T12:24:31Z | - |
dc.date.available | 2021-09-02T12:24:31Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 1540-7535 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75999 | - |
dc.description.abstract | We aimed to determine the antioxidant and neuronal cell protective effects of jujube (Ziziphus jujuba) leaf solvent fractions. The butanol fraction from jujube showed potent antioxidant activity in each assay, and its ABTS radical scavenging effect, FRAP, and MDA inhibition increased in a dose-dependent manner. Following H2O2 treatment, intracellular ROS accumulation significantly reduced when butanol fraction from jujube leaf was present in the PC12 cell media. In the MTT cell viability assay, the butanol fraction showed a protective effect against H2O2-induced neurotoxicity and inhibited LDH release into the medium (7.13-43.89%). Total phenols of the three solvent fractions were 72.50 (chloroform), 297.18 (butanol), and 17.93 (water) mg/g GAE. The predominant phenolic compounds in jujube leaves are rutin (57.07 mg/100 g) and quercetin (9.27 mg/100 g). These data suggest that butanol fraction from jujube leaf including phenolics may be useful natural antioxidants to reduce the risk of neurodegenerative diseases including Alzheimer's disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NEW CENTURY HEALTH PUBLISHERS, LLC | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | VITAMIN-C | - |
dc.subject | TEA | - |
dc.subject | CAPACITY | - |
dc.subject | EXTRACT | - |
dc.subject | TANNINS | - |
dc.title | PROTECTIVE EFFECTS OF PHENOLICS FROM JUJUBE (ZIZIPHUS JUJUBA) LEAF AGAINST H2O2-INDUCED OXIDATIVE STRESS IN NEURONAL PC-12 CELLS | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chi, Young Min | - |
dc.identifier.wosid | 000440958400003 | - |
dc.identifier.bibliographicCitation | CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, v.16, no.2, pp.129 - 137 | - |
dc.relation.isPartOf | CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | - |
dc.citation.title | CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 129 | - |
dc.citation.endPage | 137 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | VITAMIN-C | - |
dc.subject.keywordPlus | TEA | - |
dc.subject.keywordPlus | CAPACITY | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | TANNINS | - |
dc.subject.keywordAuthor | Antioxidants | - |
dc.subject.keywordAuthor | Cell viability | - |
dc.subject.keywordAuthor | Jujube leaf | - |
dc.subject.keywordAuthor | Neuronal protective effect | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.