Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment
DC Field | Value | Language |
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dc.contributor.author | Chun, Haejin | - |
dc.contributor.author | Yeom, Minjoo | - |
dc.contributor.author | Kim, Hyun-Ouk | - |
dc.contributor.author | Lim, Jong-Woo | - |
dc.contributor.author | Na, Woonsung | - |
dc.contributor.author | Park, Geunseon | - |
dc.contributor.author | Park, Chaewon | - |
dc.contributor.author | Kang, Aram | - |
dc.contributor.author | Yun, Dayeon | - |
dc.contributor.author | Kim, Jihye | - |
dc.contributor.author | Song, Daesub | - |
dc.contributor.author | Haam, Seungjoo | - |
dc.date.accessioned | 2021-09-02T12:34:53Z | - |
dc.date.available | 2021-09-02T12:34:53Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04-28 | - |
dc.identifier.issn | 1759-9954 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76088 | - |
dc.description.abstract | Influenza A virus (IAV), which causes one of the most contagious diseases, is a global health concern and is responsible for seasonal epidemics and pandemics. Despite notable efforts towards developing antiviral agents and drugs, a vast majority of these, especially intracellular drugs, have shown limited efficacy due to non-specificity and low viability under physiological or endosomal conditions. Polymersomes consist of phenylboronic acid (PBA) pendant group polymers (PBASomes) and can act as drug carriers; they have sialic acid-targeting properties and can gain greater access to the intracellular space for the transport of antivirals within the host cell. Amphiphilic copolymers comprising methoxy-poly(ethylene glycol)-block-poly(phenylalanine) (mPEG-b-pPhe) formed polymersomes, which encapsulated mir-323a in the core and favipiravir in the exterior layer as hydrophilic and hydrophobic antivirals, respectively. For maximizing the cellular uptake of PBASomes via receptor-mediated endocytosis, the surface density of PBA was controlled with PBA-functionalized copolymers (PBA-PEG-pPhe). Combination therapy by employing polymersomes with PBA functional groups induced a synergistic effect against H1N1 virus infection in vitro. We believe that antiviral co-delivery using these polymersomes would provide better opportunities to improve transfection of therapeutic substances for IAV treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | HUMAN BILIARY CANCER | - |
dc.subject | FAVIPIRAVIR T-705 | - |
dc.subject | INFECTED-CELLS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | DRUGS | - |
dc.subject | ENDOCYTOSIS | - |
dc.subject | GEMCITABINE | - |
dc.subject | MECHANISMS | - |
dc.subject | PACLITAXEL | - |
dc.subject | REPULSION | - |
dc.title | Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Woonsung | - |
dc.contributor.affiliatedAuthor | Song, Daesub | - |
dc.identifier.doi | 10.1039/c8py00116b | - |
dc.identifier.scopusid | 2-s2.0-85045919314 | - |
dc.identifier.wosid | 000430933900007 | - |
dc.identifier.bibliographicCitation | POLYMER CHEMISTRY, v.9, no.16, pp.2116 - 2123 | - |
dc.relation.isPartOf | POLYMER CHEMISTRY | - |
dc.citation.title | POLYMER CHEMISTRY | - |
dc.citation.volume | 9 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 2116 | - |
dc.citation.endPage | 2123 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | HUMAN BILIARY CANCER | - |
dc.subject.keywordPlus | FAVIPIRAVIR T-705 | - |
dc.subject.keywordPlus | INFECTED-CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | ENDOCYTOSIS | - |
dc.subject.keywordPlus | GEMCITABINE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | REPULSION | - |
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