E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
DC Field | Value | Language |
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dc.contributor.author | Horne, Hisani N. | - |
dc.contributor.author | Oh, Hannah | - |
dc.contributor.author | Sherman, Mark E. | - |
dc.contributor.author | Palakal, Maya | - |
dc.contributor.author | Hewitt, Stephen M. | - |
dc.contributor.author | Schmidt, Marjanka K. | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | Hardisson, David | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Blomqvist, Carl | - |
dc.contributor.author | Bolla, Manjeet K. | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Cora, Renata | - |
dc.contributor.author | Couch, Fergus J. | - |
dc.contributor.author | Cuk, Katarina | - |
dc.contributor.author | Devilee, Peter | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Eccles, Diana M. | - |
dc.contributor.author | Eilber, Ursula | - |
dc.contributor.author | Hartikainen, Jaana M. | - |
dc.contributor.author | Heikkila, Paivi | - |
dc.contributor.author | Holleczek, Bernd | - |
dc.contributor.author | Hooning, Maartje J. | - |
dc.contributor.author | Jones, Michael | - |
dc.contributor.author | Keeman, Renske | - |
dc.contributor.author | Mannermaa, Arto | - |
dc.contributor.author | Martens, John W. M. | - |
dc.contributor.author | Muranen, Taru A. | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Olson, Janet E. | - |
dc.contributor.author | Orr, Nick | - |
dc.contributor.author | Perez, Jose I. A. | - |
dc.contributor.author | Pharoah, Paul D. P. | - |
dc.contributor.author | Ruddy, Kathryn J. | - |
dc.contributor.author | Saum, Kai-Uwe | - |
dc.contributor.author | Schoemaker, Minouk J. | - |
dc.contributor.author | Seynaeve, Caroline | - |
dc.contributor.author | Sironen, Reijo | - |
dc.contributor.author | Smit, Vincent T. H. B. M. | - |
dc.contributor.author | Swerdlow, Anthony J. | - |
dc.contributor.author | Tengstrom, Maria | - |
dc.contributor.author | Thomas, Abigail S. | - |
dc.contributor.author | Timmermans, A. Mieke | - |
dc.contributor.author | Tollenaar, Rob A. E. M. | - |
dc.contributor.author | Troester, Melissa A. | - |
dc.contributor.author | van Asperen, Christi J. | - |
dc.contributor.author | van Deurzen, Carolien H. M. | - |
dc.contributor.author | Van Leeuwen, Flora F. | - |
dc.contributor.author | Van'tVeer, Laura J. | - |
dc.contributor.author | Garcia-Closas, Montserrat | - |
dc.contributor.author | Figueroa, Jonine D. | - |
dc.date.accessioned | 2021-09-02T12:35:27Z | - |
dc.date.available | 2021-09-02T12:35:27Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04-26 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76092 | - |
dc.description.abstract | E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, > 2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | COMPREHENSIVE MOLECULAR PORTRAITS | - |
dc.subject | HORMONE REPLACEMENT THERAPY | - |
dc.subject | INVASIVE LOBULAR CARCINOMA | - |
dc.subject | RECEPTOR STATUS | - |
dc.subject | MALIGNANT PROGRESSION | - |
dc.subject | METASTATIC LESIONS | - |
dc.subject | ESTROGEN-RECEPTOR | - |
dc.subject | CLINICAL-TRIALS | - |
dc.subject | HISTOLOGIC TYPE | - |
dc.subject | UNITED-STATES | - |
dc.title | E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Hannah | - |
dc.identifier.doi | 10.1038/s41598-018-23733-4 | - |
dc.identifier.scopusid | 2-s2.0-85045981399 | - |
dc.identifier.wosid | 000430919900023 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | COMPREHENSIVE MOLECULAR PORTRAITS | - |
dc.subject.keywordPlus | HORMONE REPLACEMENT THERAPY | - |
dc.subject.keywordPlus | INVASIVE LOBULAR CARCINOMA | - |
dc.subject.keywordPlus | RECEPTOR STATUS | - |
dc.subject.keywordPlus | MALIGNANT PROGRESSION | - |
dc.subject.keywordPlus | METASTATIC LESIONS | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | CLINICAL-TRIALS | - |
dc.subject.keywordPlus | HISTOLOGIC TYPE | - |
dc.subject.keywordPlus | UNITED-STATES | - |
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