Intense Red-Emitting Upconversion Nanophosphors (800 nm-Driven) with a Core/Double-Shell Structure for Dual-Modal Upconversion Luminescence and Magnetic Resonance in Vivo Imaging Applications
- Authors
- Hong, A-Ra; Kim, Youngsun; Lee, Tae Sup; Kim, Sehoon; Lee, Kwangyeol; Kim, Gayoung; Jang, Ho Seong
- Issue Date
- 18-4월-2018
- Publisher
- AMER CHEMICAL SOC
- Keywords
- core/shell/shell; upconversion; nanophosphors; in vivo fluorescence imaging in vivo magnetic resonance imaging
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.10, no.15, pp.12331 - 12340
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 10
- Number
- 15
- Start Page
- 12331
- End Page
- 12340
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/76116
- DOI
- 10.1021/acsami.7b18078
- ISSN
- 1944-8244
- Abstract
- In this study, intense single-band red-emitting upconversion nanophosphors (UCNPs) excited with 800 nm near-infrared (NIR) light are reported. When a NaYF4:Nd,Yb active-shell is formed on the 12.7 nm sized NaGdF4:Yb,Ho,Ce UCNP core, the core/shell (C/S) UCNPs show tunable emission from green to red, depending on the Ce3+ concentration under excitation with 800 nm NIR light. Ce(3+)doped C/S UCNPs (30 mol %) exhibit single-band red emission peaking at 644 nm via a F-5(5) -> I-5(8) transition of Ho3+. A high Nd3+ concentration in the shell results in strong absorption at around 800 nm NIR light, even though the shell thickness is not large, and small-sized C/S UCNPs (16.3 nm) emit bright red light under 800 nm excitation. The formation of a thin NaGdF4 shell on the C/S UCNPs further enhances the upconversion (UC) luminescence and sub-20 nm sized core/double-shell (C/D-S) UCNPs exhibit 2.8 times stronger UC luminescence compared with C/S UCNPs. Owing to the strong UC luminescence intensity and Gd3+ ions on the surface of nanocrystals, they can be applied as a UC luminescence imaging agent and a T-1 contrast agent for magnetic resonance (MR) imaging. In vivo UC luminescence and high-contrast MR images are successfully obtained by utilizing the red-emitting C/D-S UCNPs.
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