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Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jin, Qinghao | - |
| dc.contributor.author | Han, Xiang Hua | - |
| dc.contributor.author | Yun, Cheong-Yong | - |
| dc.contributor.author | Lee, Chul | - |
| dc.contributor.author | Lee, Jin Woo | - |
| dc.contributor.author | Lee, Dongho | - |
| dc.contributor.author | Lee, Mi Kyeong | - |
| dc.contributor.author | Jung, Sang-Hun | - |
| dc.contributor.author | Hong, Jin Tae | - |
| dc.contributor.author | Kim, Youngsoo | - |
| dc.contributor.author | Hwang, Bang Yeon | - |
| dc.date.accessioned | 2021-09-02T12:41:17Z | - |
| dc.date.available | 2021-09-02T12:41:17Z | - |
| dc.date.created | 2021-06-16 | - |
| dc.date.issued | 2018-04-15 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76135 | - |
| dc.description.abstract | Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in a-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dosedependently inhibited the melanin production with the IC50 values ranging from 4 mu M to 33 mu M. (C) 2018 Elsevier Ltd. All rights reserved. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.subject | C-21 STEROIDAL GLYCOSIDES | - |
| dc.subject | ROOTS | - |
| dc.subject | CONSTITUENTS | - |
| dc.subject | TYROSINASE | - |
| dc.title | Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Lee, Dongho | - |
| dc.identifier.doi | 10.1016/j.bmcl.2018.01.004 | - |
| dc.identifier.scopusid | 2-s2.0-85042911641 | - |
| dc.identifier.wosid | 000428092400018 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.28, no.7, pp.1252 - 1256 | - |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 28 | - |
| dc.citation.number | 7 | - |
| dc.citation.startPage | 1252 | - |
| dc.citation.endPage | 1256 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | C-21 STEROIDAL GLYCOSIDES | - |
| dc.subject.keywordPlus | ROOTS | - |
| dc.subject.keywordPlus | CONSTITUENTS | - |
| dc.subject.keywordPlus | TYROSINASE | - |
| dc.subject.keywordAuthor | Cynanchum atratum | - |
| dc.subject.keywordAuthor | Asclepiadaceae | - |
| dc.subject.keywordAuthor | Pregnane glycosides | - |
| dc.subject.keywordAuthor | alpha-MSH | - |
| dc.subject.keywordAuthor | Melanogenesis inhibitor | - |
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology