Network approach of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation
DC Field | Value | Language |
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dc.contributor.author | Yoon, Hyun Jung | - |
dc.contributor.author | Lee, Sungmin | - |
dc.contributor.author | Park, Sun Joo | - |
dc.contributor.author | Wu, Sangwook | - |
dc.date.accessioned | 2021-09-02T12:44:58Z | - |
dc.date.available | 2021-09-02T12:44:58Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04-04 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76166 | - |
dc.description.abstract | Non-receptor tyrosine kinase c-Src plays a critical role in numerous cellular signalling pathways. Activation of c-Src from its inactive to the active state involves large-scale conformational changes, and is controlled by the phosphorylation state of two major phosphorylation sites, Tyr416 and Tyr527. A detailed mechanism for the entire conformational transition of c-Src via phosphorylation control of Tyr416 and Tyr527 is still elusive. In this study, we investigated the inactive-to-active conformational change of c-Src by targeted molecular dynamics simulation. Based on the simulation, we proposed a dynamical scenario for the activation process of c-Src. A detailed study of the conformational transition pathway based on network analysis suggests that Lys321 plays a key role in the c-Src activation process. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CROSS-CORRELATION ANALYSIS | - |
dc.subject | COMPLEX NETWORKS | - |
dc.subject | FAMILY KINASES | - |
dc.subject | BREAST-CANCER | - |
dc.subject | PROTEIN | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | DISTRIBUTIONS | - |
dc.subject | FLUCTUATION | - |
dc.subject | CENTRALITY | - |
dc.subject | MECHANICS | - |
dc.title | Network approach of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sungmin | - |
dc.identifier.doi | 10.1038/s41598-018-23964-5 | - |
dc.identifier.scopusid | 2-s2.0-85044918871 | - |
dc.identifier.wosid | 000429095600082 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CROSS-CORRELATION ANALYSIS | - |
dc.subject.keywordPlus | COMPLEX NETWORKS | - |
dc.subject.keywordPlus | FAMILY KINASES | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DISTRIBUTIONS | - |
dc.subject.keywordPlus | FLUCTUATION | - |
dc.subject.keywordPlus | CENTRALITY | - |
dc.subject.keywordPlus | MECHANICS | - |
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