Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography

Authors
Nam, Hyeong SooKang, Woo JaeLee, Min WooSong, Joon WooKim, Jin WonOh, Wang-YuhlYoo, Hongki
Issue Date
1-4월-2018
Publisher
OPTICAL SOC AMER
Citation
BIOMEDICAL OPTICS EXPRESS, v.9, no.4, pp.1930 - 1947
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICAL OPTICS EXPRESS
Volume
9
Number
4
Start Page
1930
End Page
1947
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/76175
DOI
10.1364/BOE.9.001930
ISSN
2156-7085
Abstract
The pathophysiological progression of chronic diseases, including atherosclerosis and cancer, is closely related to compositional changes in biological tissues containing endogenous fluorophores such as collagen, elastin, and NADH, which exhibit strong autofluorescence under ultraviolet excitation. Fluorescence lifetime imaging (FLIm) provides robust detection of the compositional changes by measuring fluorescence lifetime, which is an inherent property of a fluorophore. In this paper, we present a dual-modality system combining a multispectral analog-mean-delay (AMD) FLIm and a high-speed swept-source optical coherence tomography (OCT) to simultaneously visualize the cross-sectional morphology and biochemical compositional information of a biological tissue. Experiments using standard fluorescent solutions showed that the fluorescence lifetime could be measured with a precision of less than 40 psec using the multispectral AMD-FLIm without averaging. In addition, we performed ex vivo imaging on rabbit iliac normal-looking and atherosclerotic specimens to demonstrate the feasibility of the combined FLIm-OCT system for atherosclerosis imaging. We expect that the combined FLIm-OCT will be a promising nextgeneration imaging technique for diagnosing atherosclerosis and cancer due to the advantages of the proposed label-free high-precision multispectral lifetime measurement. (c) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Jin Won photo

Kim, Jin Won
의과학과
Read more

Altmetrics

Total Views & Downloads

BROWSE