Cell-specific expression and signal transduction of C-C motif chemokine ligand 2 and atypical chemokine receptors in the porcine endometrium during early pregnancy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Whasun | - |
dc.contributor.author | Bae, Hyocheol | - |
dc.contributor.author | Bazer, Fuller W. | - |
dc.contributor.author | Song, Gwonhwa | - |
dc.date.accessioned | 2021-09-02T12:46:51Z | - |
dc.date.available | 2021-09-02T12:46:51Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 0145-305X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76183 | - |
dc.description.abstract | Chemokines and atypical chemokine receptors (ACKRs; also known as chemokine decoy receptors) play an important role in reproductive immunology by recruiting leukocytes during early pregnancy. The aim of this study was to determine the expression of C-C motif chemokine ligand 2 (CCL2) and ACKRs in the endometrium during estrous cycle and early pregnancy, and to investigate the functional effects of CCL2 on porcine uterine luminal epithelial (pLE) cells. Our results indicated that CCL2, ACKR1, ACKR3, and ACKR4 were strongly detected in the glandular and luminal epithelium of the endometrium during early pregnancy compared to that in non-pregnant pigs. Recombinant CCL2 improved pLE cell proliferation via activation of the PI3K and MAPK pathways and suppression of endoplasmic reticulum (ER) stress by reducing the expression of ER stress regulatory genes. Collectively, these results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | LEUKEMIA-INHIBITORY FACTOR | - |
dc.subject | MATERNAL-FETAL INTERFACE | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | UNFOLDED PROTEIN RESPONSE | - |
dc.subject | DECIDUAL STROMAL CELLS | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | DIFFERENTIAL EXPRESSION | - |
dc.subject | EMBRYO IMPLANTATION | - |
dc.subject | HUMAN PLACENTA | - |
dc.subject | GROWTH-FACTORS | - |
dc.title | Cell-specific expression and signal transduction of C-C motif chemokine ligand 2 and atypical chemokine receptors in the porcine endometrium during early pregnancy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwonhwa | - |
dc.identifier.doi | 10.1016/j.dci.2017.12.020 | - |
dc.identifier.scopusid | 2-s2.0-85042363633 | - |
dc.identifier.wosid | 000424726900032 | - |
dc.identifier.bibliographicCitation | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, v.81, pp.312 - 323 | - |
dc.relation.isPartOf | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | - |
dc.citation.title | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | - |
dc.citation.volume | 81 | - |
dc.citation.startPage | 312 | - |
dc.citation.endPage | 323 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Fisheries | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Fisheries | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.subject.keywordPlus | LEUKEMIA-INHIBITORY FACTOR | - |
dc.subject.keywordPlus | MATERNAL-FETAL INTERFACE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | DECIDUAL STROMAL CELLS | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION | - |
dc.subject.keywordPlus | EMBRYO IMPLANTATION | - |
dc.subject.keywordPlus | HUMAN PLACENTA | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordAuthor | CCL2 | - |
dc.subject.keywordAuthor | ACKR | - |
dc.subject.keywordAuthor | Endometrium | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Porcine | - |
dc.subject.keywordAuthor | Lumina epithelial cell | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.