Cordyceps militaris Extract Inhibits the NF-KB pathway and Induces Apoptosis through MKK7-JNK Signaling Activation in TK-10 Human Renal Cell Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Park, Soo Jung | - |
dc.contributor.author | Jang, Hyun-Jin | - |
dc.contributor.author | Hwang, In-Hu | - |
dc.contributor.author | Kim, Jung Min | - |
dc.contributor.author | Jo, Eunbi | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Jang, Ik-Soon | - |
dc.contributor.author | Joo, Jong Cheon | - |
dc.date.accessioned | 2021-09-02T12:47:35Z | - |
dc.date.available | 2021-09-02T12:47:35Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1934-578X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76190 | - |
dc.description.abstract | The ubiquitous transcription factor, NF-KB, has been reported to inhibit apoptosis and induce drug resistance in cancer cells. Cordyceps militaris extract (CME) is involved in the regulation of the NF-KB signaling pathway. However, the detailed role of CME in the suppression of the NF-KB signaling pathway is unclear. We found that CME dose-dependently inhibited tumor necrosis factor-alpha (TNF-alpha)-induced NF-KB activation in TK-10 human renal cell carcinoma. CME prevented NF-KB from translocating to the nucleus, which resulted in the downregulation of GADD45B, upregulation of MKK7, and phosphorylation of JNK (p-JNK). The increased activation of Bax led to pronounced CME-induced apoptosis, which occurred through caspase-3. Furthermore, the siRNA-mediated knockdown of GADD45B inhibited MKK7 expression, whereas the siRNA-mediated inhibition of MKK7 downregulated p-JNK and the JNK inhibitor, SP600125, inhibited Bax expression. Thus, these results indicated that CME inhibited the activation of GADD45B via the inhibition of NF-KB activation, which upregulated the MKK7-JNK signaling pathway to induce apoptosis in TK-10 cells. Thus, this study reveals a novel anticancer function of CME. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | KAPPA-B | - |
dc.subject | CANCER | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INDUCTION | - |
dc.subject | GROWTH | - |
dc.title | Cordyceps militaris Extract Inhibits the NF-KB pathway and Induces Apoptosis through MKK7-JNK Signaling Activation in TK-10 Human Renal Cell Carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, In-Hu | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.identifier.scopusid | 2-s2.0-85048095503 | - |
dc.identifier.wosid | 000433651900022 | - |
dc.identifier.bibliographicCitation | NATURAL PRODUCT COMMUNICATIONS, v.13, no.4, pp.465 - 470 | - |
dc.relation.isPartOf | NATURAL PRODUCT COMMUNICATIONS | - |
dc.citation.title | NATURAL PRODUCT COMMUNICATIONS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 465 | - |
dc.citation.endPage | 470 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Cordyceps militaris | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | NF-KB | - |
dc.subject.keywordAuthor | MKK7 | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | TK-10. | - |
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