Supramolecular Analysis of Monosaccharide Derivatives Using Cucurbit[7]uril and Electrospray Ionization Tandem Mass Spectrometry
- Authors
- Lee, Hyun Hee L.; Kim, Hugh I.
- Issue Date
- 4월-2018
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- carbohydrates; host-guest systems; mass spectrometry; supramolecular chemistry
- Citation
- ISRAEL JOURNAL OF CHEMISTRY, v.58, no.3-4, pp.472 - 478
- Indexed
- SCIE
SCOPUS
- Journal Title
- ISRAEL JOURNAL OF CHEMISTRY
- Volume
- 58
- Number
- 3-4
- Start Page
- 472
- End Page
- 478
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/76218
- DOI
- 10.1002/ijch.201700073
- ISSN
- 0021-2148
- Abstract
- Identification of monosaccharide derivatives using an analytical technique is difficult due to their isomeric structures and similar physical properties. Although mass spectrometry (MS) has emerged as a prominent technique for this purpose, a comprehensive MS-based method for analyzing diverse monosaccharide species is yet to be developed. Herein, we employ host-guest chemistry using cucurbit[7]uril (CB[7]) with MS to identify four different monosaccharide derivative species. Tandem MS analysis distinguishes the monosaccharide derivatives based on the unique fragmentation pattern produced when forming gas-phase complexes with CB[7]. The ion mobility studies combined with computational calculations reveal that subtle differences in isomers cause distinct orientations inside CB[7] cavity, resulting in different fragmentation patterns of the isomers. This unique study demonstrates that host-guest chemistry combined with MS can be used for developing effective isomer analysis techniques.
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