Capillary rarefaction and altered renal development: the imbalance between pro- and anti-angiogenic factors in response to angiotensin II inhibition in the developing rat kidney
DC Field | Value | Language |
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dc.contributor.author | Yoo, Kee Hwan | - |
dc.contributor.author | Yim, Hyung Eun | - |
dc.contributor.author | Bae, Eun Soo | - |
dc.contributor.author | Hong, Young Sook | - |
dc.date.accessioned | 2021-09-02T13:31:34Z | - |
dc.date.available | 2021-09-02T13:31:34Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1567-2379 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76624 | - |
dc.description.abstract | Proper and timely assembly of the kidney vasculature with their respective nephrons is crucial during normal kidney development. In this study, we investigated the effects of enalapril (angiotensin-converting enzyme inhibitor) on angiogenesis-related gene expression and microvascular endothelium related to glomeular and tubular changes in the neonatal rat kidney. Enalapril-treated rats had higher tubular injury scores and lower glomerular maturity grades than those of untreated rats. In the enalapril-treated group, intrarenal angiopoietin-2, Tie-2, and thrombospondin-1 protein expression increased, whereas intrarenal angiopoietin-1 protein expression decreased. JG12-positive glomerular and peritubular capillary staining was reduced in the enalapril-treated rat kidney. The number of JG12-positive capillary endothelial cells was directly correlated with glomerular maturation grade and was inversely related with the tubular injury. Our findings suggest the imbalance between pro- and anti-angiogenic factors may be implicated in the loss of capillaries in associated with impaired nephrogenesis after angiotensin II blockade in the developing rat kidney. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | ACE-INHIBITION | - |
dc.subject | URETERAL OBSTRUCTION | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | EXPRESSION | - |
dc.subject | THROMBOSPONDIN-1 | - |
dc.subject | FIBROSIS | - |
dc.subject | GROWTH | - |
dc.subject | RENIN | - |
dc.subject | INFLAMMATION | - |
dc.title | Capillary rarefaction and altered renal development: the imbalance between pro- and anti-angiogenic factors in response to angiotensin II inhibition in the developing rat kidney | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Kee Hwan | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Eun | - |
dc.contributor.affiliatedAuthor | Hong, Young Sook | - |
dc.identifier.doi | 10.1007/s10735-018-9762-7 | - |
dc.identifier.scopusid | 2-s2.0-85041895764 | - |
dc.identifier.wosid | 000426938000011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR HISTOLOGY, v.49, no.2, pp.219 - 228 | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR HISTOLOGY | - |
dc.citation.title | JOURNAL OF MOLECULAR HISTOLOGY | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 219 | - |
dc.citation.endPage | 228 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | ACE-INHIBITION | - |
dc.subject.keywordPlus | URETERAL OBSTRUCTION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | THROMBOSPONDIN-1 | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | RENIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | Angiopoietins | - |
dc.subject.keywordAuthor | Neovascularization | - |
dc.subject.keywordAuthor | Pathologic | - |
dc.subject.keywordAuthor | Renin-angiotensin system | - |
dc.subject.keywordAuthor | Thrombospondin-1 | - |
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