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Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Authors
Kim, Sung BongZhang, YiWon, Sang MinBandodkar, Amay J.Sekine, YurinaXue, YeguangKoo, JahyunHarshman, Sean W.Martin, Jennifer A.Park, Jeong MinRay, Tyler R.Crawford, Kaitlyn E.Lee, Kyu-TaeChoi, JungilPitsch, Rhonda L.Grigsby, Claude C.Strang, Adam J.Chen, Yu-YuXu, ShuaiKim, JeonghyunKoh, AhyeonHa, Jeong SookHuang, YonggangKim, Seung WookRogers, John A.
Issue Date
22-3월-2018
Publisher
WILEY-V C H VERLAG GMBH
Keywords
microfluidics; perspiration; super absorbent polymer; sweat chloride
Citation
SMALL, v.14, no.12
Indexed
SCIE
SCOPUS
Journal Title
SMALL
Volume
14
Number
12
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/76695
DOI
10.1002/smll.201703334
ISSN
1613-6810
Abstract
This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.
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Ha, Jeong Sook
공과대학 (화공생명공학과)
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