HbA1c Cutoff for Prediabetes and Diabetes Based on Oral Glucose Tolerance Test in Obese Children and Adolescents
DC Field | Value | Language |
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dc.contributor.author | Nam, Hyo-Kyoung | - |
dc.contributor.author | Cho, Won Kyoung | - |
dc.contributor.author | Kim, Jae Hyun | - |
dc.contributor.author | Rhie, Young-Jun | - |
dc.contributor.author | Chung, Sochung | - |
dc.contributor.author | Lee, Kee-Hyoung | - |
dc.contributor.author | Suh, Byung-Kyu | - |
dc.date.accessioned | 2021-09-02T13:43:57Z | - |
dc.date.available | 2021-09-02T13:43:57Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03-19 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76705 | - |
dc.description.abstract | Background: Oral glucose tolerance test (OGTT) is a traditional diagnostic tool for diabetes. Hemoglobin A1c (HbA1c) is an alternative method used in adults; however, its application in youths has been controversial. We evaluated the diagnostic performance of HbA1c and determined optimal cutoff points for detecting prediabetes and diabetes in youth. Methods: This retrospective study included 389 obese children (217 boys, 55.8%) who had undergone simultaneous OGTT and HbA1c testing at six hospitals, Korea, between 2010 and 2016. Subjects were diagnosed with diabetes (fasting glucose >= 7.0 mmol/L; 2-hour glucose >= 11.1 mmol/L) or prediabetes (fasting glucose 5.6-6.9 mmol/L; 2-hour glucose 7.8-11.0 mmol/L). The diagnostic performance of HbA1c for prediabetes and diabetes was determined using the area under the receiver operating characteristic curve (AUC). Results: At diagnosis, 197 (50.6%) subjects had normoglycemia, 121 (31.1%) had prediabetes, and 71 (18.3%) had diabetes. The kappa coefficient for agreement between OGTT and HbA1c was 0.464. The optimal HbA1c cutoff points were 5.8% (AUC, 0.795; a sensitivity of 64.1% and a specificity of 83.8%) for prediabetes and 6.2% (AUC, 0.972; a sensitivity of 91.5% and a specificity of 93.7%) for diabetes. When HbA1c (>= 6.2%) and 2-hour glucose level were used to diagnose diabetes, 100% were detected. Conclusion: Pediatric criteria for HbA1c remain unclear, therefore, we recommend the combination of fasting and 2-hour glucose levels, in addition to HbA1c, in the diagnosis of childhood prediabetes and diabetes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | HEMOGLOBIN A(1C) | - |
dc.subject | FASTING GLUCOSE | - |
dc.subject | RISK | - |
dc.subject | A1C | - |
dc.subject | INDIVIDUALS | - |
dc.subject | PREVALENCE | - |
dc.subject | DIAGNOSIS | - |
dc.subject | UTILITY | - |
dc.subject | OGTT | - |
dc.title | HbA1c Cutoff for Prediabetes and Diabetes Based on Oral Glucose Tolerance Test in Obese Children and Adolescents | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Hyo-Kyoung | - |
dc.contributor.affiliatedAuthor | Rhie, Young-Jun | - |
dc.contributor.affiliatedAuthor | Lee, Kee-Hyoung | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e93 | - |
dc.identifier.scopusid | 2-s2.0-85044407275 | - |
dc.identifier.wosid | 000428150100005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.12 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002325014 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | HEMOGLOBIN A(1C) | - |
dc.subject.keywordPlus | FASTING GLUCOSE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | A1C | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | UTILITY | - |
dc.subject.keywordPlus | OGTT | - |
dc.subject.keywordAuthor | Diabetes Mellitus | - |
dc.subject.keywordAuthor | Diagnosis | - |
dc.subject.keywordAuthor | Glucose Tolerance Test | - |
dc.subject.keywordAuthor | HbA1c | - |
dc.subject.keywordAuthor | Prediabetic State | - |
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