Temporal changes in the neutrophil to lymphocyte ratio and the neurological progression in cryptogenic stroke with active cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Ki-Woong | - |
dc.contributor.author | Kim, Tae Jung | - |
dc.contributor.author | Kim, Chi Kyung | - |
dc.contributor.author | Mo, Heejung | - |
dc.contributor.author | Jeong, Han-Yeong | - |
dc.contributor.author | Kang, Min Kyoung | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Ko, Sang-Bae | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.date.accessioned | 2021-09-02T13:45:14Z | - |
dc.date.available | 2021-09-02T13:45:14Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03-16 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76715 | - |
dc.description.abstract | Background Ischemic stroke patients with active cancer frequently experience early neurological deterioration (END); however, the predictors of END are not well studied. The neutrophil to lymphocyte ratio (NLR) has recently been described as a predictor of poor outcomes in cancer and stroke. However, its role in cancer-related stroke has not been addressed. Aim We aimed to evaluate the association between the NLR and END in cancer-related stroke patients. Methods We included 85 cryptogenic stroke patients with active cancer. END was defined as an increase >= 4 on the total National Institutes of Health Stroke Scale (NIHSS) score within 72 hours of admission. The NLR was calculated as the ratio of the absolute neutrophil count to the absolute lymphocyte count. We obtained the NLR during the following three periods: at admission, 1 +/- 3 days after admission (D 1 +/- 3 NLR) and 4 +/- 7 days after admission (D 4 +/- 7 NLR). Results END occurred in 15 (18%) of the 85 patients. END was significantly associated with the initial NIHSS score, infarction volume, and the D 1 +/- 3 NLR. In multivariate analysis, a higher D 1 +/- 3 NLR, measured before END events, remained an independent predictor of END [adjusted odds ratio = 2.78, 95% confidence interval = 1.09 +/- 7.08, P = 0.032]. In terms of temporal changes in the NLR, the END group showed a tendency toward temporal increase in the NLR at D 1 +/- 3 (P = 0.061) with subsequent decrements in the D 4 +/- 7 NLR (P = 0.088), while the non-END group showed no significant changes in the NLR between periods. Conclusions This study demonstrated that a higher NLR could predict END events in cryptogenic stroke patients with active cancer. However, the results should be confirmed in further large prospective studies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | PREDICTS SURVIVAL | - |
dc.subject | PRETREATMENT NEUTROPHIL | - |
dc.subject | DETERIORATION | - |
dc.subject | MORTALITY | - |
dc.subject | VOLUME | - |
dc.subject | STAGE | - |
dc.subject | RISK | - |
dc.title | Temporal changes in the neutrophil to lymphocyte ratio and the neurological progression in cryptogenic stroke with active cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chi Kyung | - |
dc.identifier.doi | 10.1371/journal.pone.0194286 | - |
dc.identifier.scopusid | 2-s2.0-85044120668 | - |
dc.identifier.wosid | 000427703500030 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.13, no.3 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | PREDICTS SURVIVAL | - |
dc.subject.keywordPlus | PRETREATMENT NEUTROPHIL | - |
dc.subject.keywordPlus | DETERIORATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | STAGE | - |
dc.subject.keywordPlus | RISK | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.