Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study
DC Field | Value | Language |
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dc.contributor.author | Chung, Sochung | - |
dc.contributor.author | Yoo, Jae-Ho | - |
dc.contributor.author | Choi, Jin Ho | - |
dc.contributor.author | Rhie, Young-Jun | - |
dc.contributor.author | Chae, Hyun-Wook | - |
dc.contributor.author | Kim, Jae Hyun | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.contributor.author | Shin, Choong Ho | - |
dc.contributor.author | Kim, Eun Young | - |
dc.contributor.author | Lee, Kee-Hyoung | - |
dc.date.accessioned | 2021-09-02T14:03:52Z | - |
dc.date.available | 2021-09-02T14:03:52Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 2287-1012 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76851 | - |
dc.description.abstract | Purpose: Regarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry study (LG Growth Study) was initiated to assess the safety and effectiveness of four types of rhGH products in real-life settings. Methods: A total of 4,000 children will be registered and prospectively followed up at 6-month intervals until 2 years after epiphyseal closure to collect data on treatment and adverse events, with primary interest in malignancies and growth outcomes. Results: As of 22 March 2017, approximately 50% (2,024) of the target number of patients have been included in the analysis set: growth hormone deficiency, 1,297 (64.1%); idiopathic short stature, 315 (15.6%); small for gestational age, 206 (10.2%); Turner syndrome, 197 (9.7%); and chronic renal failure, 9 (0.4%). At baseline, median age (years) was 8 (interquartile range [IQR], 5-11); 52% (1,048) were boys; and the majority were at Tanner stage I (83% based on breast/external genitalia, 97% on pubic hair). Median height standard deviation score was -2.26 (IQR, -2.69 to -2.0), and median bone age delay (years) was -1.46 (IQR, -2.26 to -0.78). Conclusion: This registry study will provide the opportunity to assess the risk of malignancies as well as the general safety data in Korean pediatric patients receiving rhGH. In addition, the long-term effectiveness of rhGH and comparative data between different disease entities will provide practical insight on the standard rhGH treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PEDIATRIC ENDOCRINOLOGY | - |
dc.subject | PREPUBERTAL CHILDREN | - |
dc.subject | HUMAN GH | - |
dc.subject | SAFETY | - |
dc.subject | EFFICACY | - |
dc.subject | LB03002 | - |
dc.subject | GUIDELINES | - |
dc.subject | THERAPY | - |
dc.title | Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhie, Young-Jun | - |
dc.contributor.affiliatedAuthor | Lee, Kee-Hyoung | - |
dc.identifier.doi | 10.6065/apem.2018.23.1.43 | - |
dc.identifier.scopusid | 2-s2.0-85061516573 | - |
dc.identifier.wosid | 000459250000009 | - |
dc.identifier.bibliographicCitation | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v.23, no.1, pp.43 - 50 | - |
dc.relation.isPartOf | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | - |
dc.citation.title | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 50 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002326622 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | PREPUBERTAL CHILDREN | - |
dc.subject.keywordPlus | HUMAN GH | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | LB03002 | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Growth hormone deficiency | - |
dc.subject.keywordAuthor | Turner syndrome | - |
dc.subject.keywordAuthor | Chronic renal failure | - |
dc.subject.keywordAuthor | Small for gestational age | - |
dc.subject.keywordAuthor | Idiopathic short stature | - |
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