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Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases

Authors
Oh, Soo-JinChoi, Young-KiShin, Ok Sarah
Issue Date
3월-2018
Publisher
YONSEI UNIV COLL MEDICINE
Keywords
Emerging infectious diseases; systems biology; systems vaccinology; vaccines; immunity
Citation
YONSEI MEDICAL JOURNAL, v.59, no.2, pp.176 - 186
Indexed
SCIE
SCOPUS
KCI
Journal Title
YONSEI MEDICAL JOURNAL
Volume
59
Number
2
Start Page
176
End Page
186
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/76891
DOI
10.3349/ymj.2018.59.2.176
ISSN
0513-5796
Abstract
Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply systems biology methods to analyze immune responses to a variety of pathogens and vaccines. Despite recent advances, computational and biological challenges impede wider application of systems biology approaches. This review highlights recent advances in the fields of systems immunology and vaccinology, and presents ways that systems biology- based platforms can be applied to accelerate a deeper understanding of the molecular mechanisms of immunity against EIDs.
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