Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: a single center experience
DC Field | Value | Language |
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dc.contributor.author | Bae, Ki Nam | - |
dc.contributor.author | Nam, Hyo-Kyoung | - |
dc.contributor.author | Rhie, Young-Jun | - |
dc.contributor.author | Song, Dae Jin | - |
dc.contributor.author | Lee, Kee-Hyoung | - |
dc.date.accessioned | 2021-09-02T14:43:01Z | - |
dc.date.available | 2021-09-02T14:43:01Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 2287-1012 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77232 | - |
dc.description.abstract | Purpose: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. Methods: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), or sufficiency (>= 30 ng/mL). Results: The mean serum vitamin D level was significantly lower (21.6 +/- 8.5 ng/mL vs. 28.0 +/- 12.0 ng/mL, P<0.001) and vitamin D deficiency prevalence was significantly higher (48% vs. 26%, P<0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. Conclusion: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PEDIATRIC ENDOCRINOLOGY | - |
dc.subject | VITAMIN-D STATUS | - |
dc.subject | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject | D DEFICIENCY | - |
dc.subject | DIAGNOSIS | - |
dc.subject | ADULTS | - |
dc.subject | CELLS | - |
dc.subject | RISK | - |
dc.title | Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: a single center experience | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Hyo-Kyoung | - |
dc.contributor.affiliatedAuthor | Rhie, Young-Jun | - |
dc.contributor.affiliatedAuthor | Lee, Kee-Hyoung | - |
dc.identifier.doi | 10.6065/apem.2018.23.1.21 | - |
dc.identifier.scopusid | 2-s2.0-85060965737 | - |
dc.identifier.wosid | 000459250000005 | - |
dc.identifier.bibliographicCitation | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v.23, no.1, pp.21 - 27 | - |
dc.relation.isPartOf | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | - |
dc.citation.title | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 27 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002326600 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | VITAMIN-D STATUS | - |
dc.subject.keywordPlus | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Type 1 | - |
dc.subject.keywordAuthor | Vitamin D deficiency | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Case-control studies | - |
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