Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons
DC Field | Value | Language |
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dc.contributor.author | Han, Rafael Taeho | - |
dc.contributor.author | Kim, Han-Byul | - |
dc.contributor.author | Kim, Young-Beom | - |
dc.contributor.author | Choi, Kyungmin | - |
dc.contributor.author | Park, Gi Yeon | - |
dc.contributor.author | Lee, Pa Reum | - |
dc.contributor.author | Lee, JaeHee | - |
dc.contributor.author | Kim, Hye Young | - |
dc.contributor.author | Park, Chul-Kyu | - |
dc.contributor.author | Kang, Youngnam | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Na, Heung Sik | - |
dc.date.accessioned | 2021-09-02T14:44:03Z | - |
dc.date.available | 2021-09-02T14:44:03Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77240 | - |
dc.description.abstract | Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In the present study, we aimed to identify which receptor could mediate the analgesic effect of intraperitoneal injection of oxytocin and its cellular mechanisms in thermal pain behavior. We found that oxytocin-induced analgesia could be reversed by d(CH2)(5)[Tyr(Me)(2), Dab(5)] AVP, a vasopressin-1a (V1a) receptor antagonist, but not by desGly-NH2-d(CH2)(5)[D-Tyr(2), Thr(4)] OVT, an oxytocin receptor antagonist. Single cell RT-PCR analysis revealed that V1a receptor, compared to oxytocin, vasopressin-1b and vasopressin-2 receptors, was more profoundly expressed in dorsal root ganglion (DRG) neurons and the expression of V1a receptor was predominant in transient receptor potential vanilloid 1 (TRPV1)-expressing DRG neurons. Fura-2 based calcium imaging experiments showed that capsaicin-induced calcium transient was significantly inhibited by oxytocin and that such inhibition was reversed by V1a receptor antagonist. Additionally, whole cell patch clamp recording demonstrated that oxytocin significantly increased potassium conductance via V1a receptor in DRG neurons. Taken together, our findings suggest that analgesic effects produced by peripheral administration of oxytocin were attributable to the activation of V1a receptor, resulting in reduction of TRPV1 activity and enhancement of potassium conductance in DRG neurons. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.subject | PRIMARY SENSORY NEURONS | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | ION CHANNELS | - |
dc.subject | PAIN | - |
dc.subject | NOCICEPTION | - |
dc.subject | MICE | - |
dc.subject | HYPERALGESIA | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISM | - |
dc.subject | PATHWAYS | - |
dc.title | Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Beom | - |
dc.contributor.affiliatedAuthor | Na, Heung Sik | - |
dc.identifier.doi | 10.4196/kjpp.2018.22.2.173 | - |
dc.identifier.scopusid | 2-s2.0-85043362120 | - |
dc.identifier.wosid | 000426608800007 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.22, no.2, pp.173 - 182 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 182 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002323922 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | PRIMARY SENSORY NEURONS | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | ION CHANNELS | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | NOCICEPTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | Dorsal root ganglion | - |
dc.subject.keywordAuthor | Electrophysiology | - |
dc.subject.keywordAuthor | Oxytocin | - |
dc.subject.keywordAuthor | Pain | - |
dc.subject.keywordAuthor | Vasopressin receptor | - |
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