Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, S. -P. | - |
dc.contributor.author | Oh, H. -N. | - |
dc.contributor.author | Choi, C. -Y. | - |
dc.contributor.author | Ahn, H. | - |
dc.contributor.author | Yun, H. S. | - |
dc.contributor.author | Chung, Y. M. | - |
dc.contributor.author | Kim, B. | - |
dc.contributor.author | Lee, S. J. | - |
dc.contributor.author | Chun, T. | - |
dc.date.accessioned | 2021-09-02T14:45:14Z | - |
dc.date.available | 2021-09-02T14:45:14Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1364-5072 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77251 | - |
dc.description.abstract | AimsIn this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis. Methods and ResultsOral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-) and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE and BP-specific serum IgG1 were decreased, whereas secretion of IFN- and BP-specific serum IgG2a was augmented upon administration of CJLP133 and CJLP243 in mice. ConclusionOral administration of L. plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response. Significance and Impact of the StudyLactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | AIRWAY HYPERRESPONSIVENESS | - |
dc.subject | MURINE MODEL | - |
dc.subject | HOUSE-DUST | - |
dc.subject | ASTHMA | - |
dc.subject | INFLAMMATION | - |
dc.subject | DERMATITIS | - |
dc.subject | PROBIOTICS | - |
dc.subject | EFFICACY | - |
dc.subject | EOTAXIN | - |
dc.subject | CELLS | - |
dc.title | Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, T. | - |
dc.identifier.doi | 10.1111/jam.13635 | - |
dc.identifier.scopusid | 2-s2.0-85041023335 | - |
dc.identifier.wosid | 000425188300016 | - |
dc.identifier.bibliographicCitation | JOURNAL OF APPLIED MICROBIOLOGY, v.124, no.3, pp.821 - 828 | - |
dc.relation.isPartOf | JOURNAL OF APPLIED MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF APPLIED MICROBIOLOGY | - |
dc.citation.volume | 124 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 821 | - |
dc.citation.endPage | 828 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | AIRWAY HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | HOUSE-DUST | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DERMATITIS | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | EOTAXIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | allergic rhinitis | - |
dc.subject.keywordAuthor | birch pollen | - |
dc.subject.keywordAuthor | CJLP133 | - |
dc.subject.keywordAuthor | CJLP243 | - |
dc.subject.keywordAuthor | Lactobacillus plantarum | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.