In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Jeon, Daniel I. | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.date.accessioned | 2021-09-02T14:52:09Z | - |
dc.date.available | 2021-09-02T14:52:09Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02-25 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77311 | - |
dc.description.abstract | Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-alpha. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IMMUNOREGULATORY CYTOKINES | - |
dc.subject | PLGA MICROSPHERES | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | ANIMAL-MODELS | - |
dc.subject | INHIBITION | - |
dc.subject | CELLS | - |
dc.subject | SUPPRESSION | - |
dc.subject | COLLAGEN | - |
dc.title | In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.identifier.doi | 10.1016/j.jiec.2017.09.016 | - |
dc.identifier.scopusid | 2-s2.0-85032633131 | - |
dc.identifier.wosid | 000424182500018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.58, pp.123 - 130 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 58 | - |
dc.citation.startPage | 123 | - |
dc.citation.endPage | 130 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002315595 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IMMUNOREGULATORY CYTOKINES | - |
dc.subject.keywordPlus | PLGA MICROSPHERES | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Porous microspheres | - |
dc.subject.keywordAuthor | Collagenase-induced Achilles tendinopathy | - |
dc.subject.keywordAuthor | Anti-inflammatory effect | - |
dc.subject.keywordAuthor | Tendon healing | - |
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