NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera
DC Field | Value | Language |
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dc.contributor.author | Ma, Jun | - |
dc.contributor.author | Ren, Quanhui | - |
dc.contributor.author | Dong, Bangjian | - |
dc.contributor.author | Shi, Zhaoyu | - |
dc.contributor.author | Zhang, Jie | - |
dc.contributor.author | Jin, Da-Qing | - |
dc.contributor.author | Xu, Jing | - |
dc.contributor.author | Ohizumi, Yasushi | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Guo, Yuanqiang | - |
dc.date.accessioned | 2021-09-02T15:08:38Z | - |
dc.date.available | 2021-09-02T15:08:38Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77426 | - |
dc.description.abstract | Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | ANTICANCER ACTIVITIES | - |
dc.subject | INOS PROTEIN | - |
dc.subject | TRITERPENOIDS | - |
dc.subject | DITERPENOIDS | - |
dc.subject | FLAVONOIDS | - |
dc.subject | EXTRACTS | - |
dc.subject | CELLS | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | METABOLITES | - |
dc.title | NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1016/j.bioorg.2017.12.008 | - |
dc.identifier.scopusid | 2-s2.0-85038834506 | - |
dc.identifier.wosid | 000425897800047 | - |
dc.identifier.bibliographicCitation | BIOORGANIC CHEMISTRY, v.76, pp.449 - 457 | - |
dc.relation.isPartOf | BIOORGANIC CHEMISTRY | - |
dc.citation.title | BIOORGANIC CHEMISTRY | - |
dc.citation.volume | 76 | - |
dc.citation.startPage | 449 | - |
dc.citation.endPage | 457 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITIES | - |
dc.subject.keywordPlus | INOS PROTEIN | - |
dc.subject.keywordPlus | TRITERPENOIDS | - |
dc.subject.keywordPlus | DITERPENOIDS | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordAuthor | Blumea balsamifera | - |
dc.subject.keywordAuthor | Sesquiterpenoids | - |
dc.subject.keywordAuthor | Diterpenoids | - |
dc.subject.keywordAuthor | NO inhibitory activities | - |
dc.subject.keywordAuthor | Molecular docking | - |
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