Sex-Specific Prognostic Significance of Obesity in Nonmetastatic Clear-Cell Renal-Cell Carcinoma in Korea: A Large Multicenter Cohort Analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwon, Tae Gyun | - |
dc.contributor.author | Kim, Hyeon Hoe | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Kim, Yong-June | - |
dc.contributor.author | Lee, Won Ki | - |
dc.date.accessioned | 2021-09-02T15:11:58Z | - |
dc.date.available | 2021-09-02T15:11:58Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1558-7673 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77455 | - |
dc.description.abstract | The prognostic value of body mass index (BMI) in relation to sex was assessed in 2097 patients with non-metastatic clear-cell renal-cell carcinoma in Korea. BMI was a favorable prognosticator in male but not female patients. The association between BMI and renal-cell carcinoma prognosis may differ by sex. Introduction: We assessed the prognostic significance of obesity in relation to sex in patients with non-metastatic clear-cell renal-cell carcinoma (nm-cRCC) in a large multicenter setting in Korea. Patients and Methods: A total of 2097 patients with nm-cRCC who underwent surgery with curative intent were enrolled from 6 institutions in Korea between April 2000 and February 2014. Obesity was determined by body mass index (BMI) before surgery. BMI was used as a continuous variable and was categorized as normal (>= 18.5 to < 25.0 kg/m(2), normal BMI) and overweight or obese (>= 25 kg/m(2), high BMI). The relationships between BMI, sex, recurrence-free survival (RFS), and cancer-specific survival (CSS) were evaluated. Results: Male patients had a greater high BMI ratio than female patients (P = .030). In men, the 5-year RFS and CSS rates in the high BMI group were greater than those in the normal BMI group (P = .003 and.006, respectively). Multivariate analyses revealed that in men, a high BMI was associated with greater RFS or CSS rates (hazard ratio: RFS, 0.901, P = .001; CSS, 0.822, P < .001). In women, there were no significant differences in the 5-year RFS and CSS rates according to BMI (P = .531 and .323, respectively), and high BMI was not associated with RFS or CSS (P = .250 and .180, respectively). Conclusion: In patients with nm-cRCC, obesity was a favorable prognosticator in male but not female patients. Therefore, the association between obesity and nm-cRCC prognosis might differ by sex. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CIG MEDIA GROUP, LP | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | CANCER INCIDENCE | - |
dc.subject | KIDNEY CANCER | - |
dc.subject | SURVIVAL | - |
dc.subject | RISK | - |
dc.subject | METAANALYSIS | - |
dc.subject | IMPACT | - |
dc.subject | OUTCOMES | - |
dc.subject | PARADOX | - |
dc.subject | SURGERY | - |
dc.title | Sex-Specific Prognostic Significance of Obesity in Nonmetastatic Clear-Cell Renal-Cell Carcinoma in Korea: A Large Multicenter Cohort Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.1016/j.clgc.2017.08.015 | - |
dc.identifier.scopusid | 2-s2.0-85029676571 | - |
dc.identifier.wosid | 000425190400020 | - |
dc.identifier.bibliographicCitation | CLINICAL GENITOURINARY CANCER, v.16, no.1, pp.E173 - E179 | - |
dc.relation.isPartOf | CLINICAL GENITOURINARY CANCER | - |
dc.citation.title | CLINICAL GENITOURINARY CANCER | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | E173 | - |
dc.citation.endPage | E179 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | CANCER INCIDENCE | - |
dc.subject.keywordPlus | KIDNEY CANCER | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | PARADOX | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordAuthor | Body mass index | - |
dc.subject.keywordAuthor | Kidney cancer | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Sex | - |
dc.subject.keywordAuthor | Survival | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.