Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Ho Won | - |
dc.contributor.author | Seo, Sung Pil | - |
dc.contributor.author | Kim, Won Tae | - |
dc.contributor.author | Yun, Seok Joong | - |
dc.contributor.author | Lee, Sang-Cheol | - |
dc.contributor.author | Kim, Wun-Jae | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwon, Tae Gyun | - |
dc.contributor.author | Kim, Hyeon Hoe | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Kim, Yong-June | - |
dc.date.accessioned | 2021-09-02T15:14:36Z | - |
dc.date.available | 2021-09-02T15:14:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1341-9625 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77477 | - |
dc.description.abstract | The prognostic implications of preoperative serum total cholesterol (TC) level in patients with renal cell carcinoma (RCC) remain poorly understood. We investigated the prognostic role of preoperative serum TC in patients with surgically treated RCC from a large, multi-institutional Korean collaboration. A database of 3064 patients with RCC who underwent radical or partial nephrectomy between 1999 and 2011 at eight academic centers was analyzed. Preoperative serum TC levels were measured in fasting blood samples. Low preoperative serum TC level was associated with aggressive tumor characteristics, including large tumor size, advanced stage, high nuclear grade, lymph node involvement, and sarcomatous differentiation (all P < 0.001). Low TC level was associated with poor recurrence-free or cancer-specific survival (CSS) in the entire cohort, whereas the significance of the association changed after stratification by disease stage and histologic subtype. Multivariate Cox regression analysis showed that preoperative TC, as a continuous or categorical variable, was an independent predictor of CSS. Preoperative low serum TC level was associated with aggressive tumor characteristics and poor CSS in patients with surgically treated RCC. Preoperative TC may provide additional guidance regarding the choice of therapeutic strategies to improve prognosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.subject | STATUS CONUT SCORE | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | CLINICAL BENEFIT | - |
dc.subject | METAANALYSIS | - |
dc.subject | NEPHRECTOMY | - |
dc.subject | GUIDELINE | - |
dc.subject | OUTCOMES | - |
dc.title | Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.1007/s10147-017-1172-4 | - |
dc.identifier.scopusid | 2-s2.0-85027039558 | - |
dc.identifier.wosid | 000424888000017 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, v.23, no.1, pp.142 - 150 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 150 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | STATUS CONUT SCORE | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | CLINICAL BENEFIT | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | NEPHRECTOMY | - |
dc.subject.keywordPlus | GUIDELINE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | Renal cell carcinoma | - |
dc.subject.keywordAuthor | Nephrectomy | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Survival | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.