Comparison of human umbilical cord blood-derived mesenchymal stem cells with healthy fibroblasts on wound-healing activity of diabetic fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Jung, Jae-A | - |
dc.contributor.author | Yoon, Young-Don | - |
dc.contributor.author | Lee, Hyup-Woo | - |
dc.contributor.author | Kang, So-Ra | - |
dc.contributor.author | Han, Seung-Kyu | - |
dc.date.accessioned | 2021-09-02T15:47:26Z | - |
dc.date.available | 2021-09-02T15:47:26Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1742-4801 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77804 | - |
dc.description.abstract | Various types of skin substitutes composed of fibroblasts and/or keratinocytes have been used for the treatment of diabetic ulcers. However, the effects have generally not been very dramatic. Recently, human umbilical cord blood-derived mesenchymal stromal cells (hUCB-MSCs) have been commercialised for cartilage repair as a first cell therapy product using allogeneic stem cells. In a previous pilot study, we reported that hUCB-MSCs have a superior wound-healing capability compared with fibroblasts. The present study was designed to compare the treatment effect of hUCB-MSCs with that of fibroblasts on the diabetic wound healing in vitro. Diabetic fibroblasts were cocultured with healthy fibroblasts or hUCB-MSCs. Five groups were evaluated: group I, diabetic fibroblasts without coculture; groups II and III, diabetic fibroblasts cocultured with healthy fibroblasts or hUCB-MSCs; and groups IV and V, no cell cocultured with healthy fibroblasts or hUCB-MSCs. After a 3-day incubation, cell proliferation, collagen synthesis levels and glycosaminoglycan levels, which are the major contributing factors in wound healing, were measured. As a result, a hUCB-MSC-treated group showed higher cell proliferation, collagen synthesis and glycosaminoglycan level than a fibroblast-treated group. In particular, there were significant statistical differences in collagen synthesis and glycosaminoglycan levels (P = 0029 and P = 0019, respectively). In conclusion, these results demonstrate that hUCB-MSCs may have a superior effect to fibroblasts in stimulating diabetic wound healing. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | MARROW STROMAL CELLS | - |
dc.subject | BONE-MARROW | - |
dc.subject | FOOT ULCERS | - |
dc.subject | DERMAL FIBROBLASTS | - |
dc.subject | IN-VITRO | - |
dc.subject | ALLOGRAFTS | - |
dc.subject | EFFICACY | - |
dc.subject | SAFETY | - |
dc.subject | TISSUE | - |
dc.title | Comparison of human umbilical cord blood-derived mesenchymal stem cells with healthy fibroblasts on wound-healing activity of diabetic fibroblasts | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jae-A | - |
dc.contributor.affiliatedAuthor | Han, Seung-Kyu | - |
dc.identifier.doi | 10.1111/iwj.12849 | - |
dc.identifier.scopusid | 2-s2.0-85041301926 | - |
dc.identifier.wosid | 000423818800018 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL WOUND JOURNAL, v.15, no.1, pp.133 - 139 | - |
dc.relation.isPartOf | INTERNATIONAL WOUND JOURNAL | - |
dc.citation.title | INTERNATIONAL WOUND JOURNAL | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 133 | - |
dc.citation.endPage | 139 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | FOOT ULCERS | - |
dc.subject.keywordPlus | DERMAL FIBROBLASTS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ALLOGRAFTS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordAuthor | diabetic wound healing | - |
dc.subject.keywordAuthor | fibroblast | - |
dc.subject.keywordAuthor | human umbilical cord blood stromal cells | - |
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