Apolipoprotein A5 3'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey
DC Field | Value | Language |
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dc.contributor.author | Kim, Oh Yoen | - |
dc.contributor.author | Moon, Jiyoung | - |
dc.contributor.author | Joe, Garam | - |
dc.contributor.author | Kwak, So-Young | - |
dc.contributor.author | Kim, Ji Young | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.date.accessioned | 2021-09-02T15:50:09Z | - |
dc.date.available | 2021-09-02T15:50:09Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/77828 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: This study aimed to test the association between APOA5 3'-UTR variants (rs662799) and cardiometabolic traits in Koreans. SUBJECTS/METHODS: For this study, epidemiological data, Apolipoprotein A5 (APOA5) genotype information, and lymphoblastoid cell line (LCL) biospecimens from a subset of the Ansung-Ansan cohort within the Korean Genome and Epidemiology study (KoGES-ASAS; n = 7,704) as well as epidemiological data along with genomic DNA biospecimens of participants from a subset of the Korea National Health and Nutrition Examination Survey (KNHANES 2011-12; n = 2,235) were obtained. APOA5 mRNA expression was also measured. RESULTS: APOA5 rs662799 genotype distributions in both the KoGES-ASAS and KNHANES groups were 50.6% for TT, 41.3% for TC, and 8.1% for CC, which are similar to those in previous reports. In both groups, minor C allele carriers, particularly subjects with CC homozygosity, had lower high-density lipoprotein (HDL) cholesterol and higher triglyceride levels than TT homozygotes. Linear regression analysis showed that the minor C allele significantly contributed to reduction of circulating HDL cholesterol levels [beta = -2.048, P < 0.001; beta = -2.199, P < 0.001] as well as elevation of circulating triglyceride levels [beta. = 0.053, P < 0.001; beta = 0.066, P < 0.001] in both the KoGES-ASAS and KNHANES groups. In addition, higher expression levels of APOA5 in LCLs of 64 healthy individuals were negatively associated with body mass index (r = -0.277, P = 0.027) and circulating triglyceride level (r = -0.340, P = 0.006) but not significantly correlated with circulating HDL cholesterol level. On the other hand, we observed no significant difference in the mRNA level of APOA5 according to APOA5 rs662799 polymorphisms. CONCLUSIONS: The C allele of APOA5 rs662799 was found to be significantly associated with cardiometabolic traits in a large Korean population from the KoGES-ASAS and KNHANES. The effect of this genotype may be associated with post-transcriptional regulation, which deserves further experimental confirmation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | DENSITY-LIPOPROTEIN CHOLESTEROL | - |
dc.subject | PLASMA TRIGLYCERIDES | - |
dc.subject | GENE POLYMORPHISM | - |
dc.subject | ISCHEMIC-STROKE | - |
dc.subject | ARTERY-DISEASE | - |
dc.subject | APOA5 | - |
dc.subject | RISK | - |
dc.subject | ASSOCIATION | - |
dc.subject | DYSLIPIDEMIA | - |
dc.title | Apolipoprotein A5 3'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.4162/nrp.2018.12.1.61 | - |
dc.identifier.scopusid | 2-s2.0-85041705547 | - |
dc.identifier.wosid | 000424964300008 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.12, no.1, pp.61 - 68 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 61 | - |
dc.citation.endPage | 68 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002313560 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | DENSITY-LIPOPROTEIN CHOLESTEROL | - |
dc.subject.keywordPlus | PLASMA TRIGLYCERIDES | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | APOA5 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DYSLIPIDEMIA | - |
dc.subject.keywordAuthor | Apolipoprotein A-V | - |
dc.subject.keywordAuthor | metabolic syndrome | - |
dc.subject.keywordAuthor | triglycerides | - |
dc.subject.keywordAuthor | Koreans | - |
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