Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA
DC Field | Value | Language |
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dc.contributor.author | Ul Mushtaq, Ameeq | - |
dc.contributor.author | Lee, Yejin | - |
dc.contributor.author | Hwang, Eunha | - |
dc.contributor.author | Bang, Jeong Kyu | - |
dc.contributor.author | Hong, Eunmi | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Song, Ji-Joon | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.date.accessioned | 2021-09-02T16:18:36Z | - |
dc.date.available | 2021-09-02T16:18:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-01-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/78024 | - |
dc.description.abstract | MeCP2 is a chromatin associated protein which is highly expressed in brain and relevant with Rett syndrome (RTT). There are AT-hook motifs in MeCP2 which can bind with AT-rich DNA, suggesting a role in chromatin binding. Here, we report the identification and characterization of another AT-rich DNA binding motif (residues 295 to 313) from the C-terminal transcription repression domain of MeCP2 by nuclear magnetic resonance (NMR) and isothermal calorimetry (ITC). This motif shows a micromolar affinity to AT-rich DNA, and it binds to the minor groove of DNA like AT-hook motifs. Together with the previous studies, our results provide an insight into a critical role of this motif in chromatin structure and function. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | BINDING PROTEIN MECP2 | - |
dc.subject | RETT-SYNDROME | - |
dc.subject | METHYL-CPG | - |
dc.subject | HOOK MOTIFS | - |
dc.subject | COMPLEX | - |
dc.subject | CHROMATIN | - |
dc.subject | RELAXATION | - |
dc.subject | DISORDERS | - |
dc.subject | SEQUENCE | - |
dc.title | Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.10.169 | - |
dc.identifier.scopusid | 2-s2.0-85033220720 | - |
dc.identifier.wosid | 000423897600023 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.495, no.1, pp.145 - 150 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 495 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 145 | - |
dc.citation.endPage | 150 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | BINDING PROTEIN MECP2 | - |
dc.subject.keywordPlus | RETT-SYNDROME | - |
dc.subject.keywordPlus | METHYL-CPG | - |
dc.subject.keywordPlus | HOOK MOTIFS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordAuthor | Methyl-CpG-binding protein 2 | - |
dc.subject.keywordAuthor | Transcription repression domain | - |
dc.subject.keywordAuthor | Basic cluster | - |
dc.subject.keywordAuthor | AT-Hook | - |
dc.subject.keywordAuthor | AT-rich DNA binding | - |
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