Surface zwitterionization: Effective method for preventing oral bacterial biofilm formation on hydroxyapatite surfaces
DC Field | Value | Language |
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dc.contributor.author | Lee, Myoungjin | - |
dc.contributor.author | Kim, Heejin | - |
dc.contributor.author | Seo, Jiae | - |
dc.contributor.author | Kang, Minji | - |
dc.contributor.author | Kang, Sunah | - |
dc.contributor.author | Jang, Joomyung | - |
dc.contributor.author | Lee, Yan | - |
dc.contributor.author | Seo, Ji-Hun | - |
dc.date.accessioned | 2021-09-02T16:19:15Z | - |
dc.date.available | 2021-09-02T16:19:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-01-01 | - |
dc.identifier.issn | 0169-4332 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/78029 | - |
dc.description.abstract | In this study, we conducted surface zwitterionization of hydroxyapatite (HA) surfaces by immersing them in the zwitterionic polymer solutions to provide anti-bacterial properties to the HA surface. Three different monomers containing various zwitterionic groups, i.e., phosphorylcholine (PC), sulfobetaine (SB), and carboxybetaine (CB), were copolymerized with the methacrylic monomer containing a Ca2+-binding moiety, using the free radical polymerization method. As a control, functionalization of the copolymer containing the Ca2+-binding moiety was synthesized using a hydroxy group. The stable immobilization of the zwitterionic functional groups was confirmed by water contact angle analysis and X-ray photoelectron spectroscopy (XPS) measurement conducted after the sonication process. The zwitterionized HA surface showed significantly decreased protein adsorption, whereas the hydroxyl group-coated HA surface showed limited efficacy. The anti-bacterial adhesion property was confirmed by conducting Streptococcus mutans (S. mutans) adhesion tests for 6 h and 24 h. When furanone C-30, a representative anti-quorum sensing molecule for S. mutans, was used, only a small amount of bacteria adhered after 6 h and the population did not increase after 24 h. In contrast, zwitterionized HA surfaces showed almost no bacterial adhesion after 6 h and the effect was retained for 24 h, resulting in the lowest level of oral bacterial adhesion. These results confirm that surface zwitterionization is a promising method to effectively prevent oral bacterial adhesion on HA-based materials. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | STREPTOCOCCUS-MUTANS BIOFILM | - |
dc.subject | PHOSPHOLIPID POLYMERS | - |
dc.subject | ADSORPTION | - |
dc.subject | SIMULATION | - |
dc.subject | MEMBRANES | - |
dc.subject | DESIGN | - |
dc.subject | WATER | - |
dc.title | Surface zwitterionization: Effective method for preventing oral bacterial biofilm formation on hydroxyapatite surfaces | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Ji-Hun | - |
dc.identifier.doi | 10.1016/j.apsusc.2017.08.067 | - |
dc.identifier.scopusid | 2-s2.0-85027546593 | - |
dc.identifier.wosid | 000415135500059 | - |
dc.identifier.bibliographicCitation | APPLIED SURFACE SCIENCE, v.427, pp.517 - 524 | - |
dc.relation.isPartOf | APPLIED SURFACE SCIENCE | - |
dc.citation.title | APPLIED SURFACE SCIENCE | - |
dc.citation.volume | 427 | - |
dc.citation.startPage | 517 | - |
dc.citation.endPage | 524 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Coatings & Films | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | STREPTOCOCCUS-MUTANS BIOFILM | - |
dc.subject.keywordPlus | PHOSPHOLIPID POLYMERS | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | SIMULATION | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordAuthor | Hydroxyapatite | - |
dc.subject.keywordAuthor | Anti-bacterial adhesion | - |
dc.subject.keywordAuthor | Anti-biofouling | - |
dc.subject.keywordAuthor | Zwitterion | - |
dc.subject.keywordAuthor | Anti-quorum sensing | - |
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