NABi, a novel beta-sheet breaker, inhibits A beta aggregation and neuronal toxicity: Therapeutic implications for Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | Jang, Ja-Young | - |
dc.contributor.author | Rhim, Hyangshuk | - |
dc.contributor.author | Kang, Seongman | - |
dc.date.accessioned | 2021-09-02T17:00:15Z | - |
dc.date.available | 2021-09-02T17:00:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0304-4165 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/78427 | - |
dc.description.abstract | Amyloid beta (A beta) aggregates are an important therapeutic target for Alzheimer's disease (AD), a fatal neuro-degenerative disease. To date, AD still remains a big challenge due to no effective treatments. Based on the property that A beta aggregates have the cross-beta-structure, a common structural feature in amyloids, we systemically designed the A beta-aggregation inhibitor that maintains A beta-interacting ability but removes toxic part from SOD1 (superoxide dismutase 1)-G93A. We identified NABi (Natural A beta Binder and A beta-aggregation inhibitor) composed of beta 2-3 strands, a novel breaker of A beta aggregation, which does not self-aggregate and has no cytotoxicity at all. The NABi blocks A beta-fibril formation in vitro and in vivo and prevents neuronal cell death, a hallmark of AD pathogenesis. Such anti-amyloidogenic properties can provide novel strategies for treating AD. Furthermore, our study provides molecular insights into the design of amyloidogenic inhibitors to cure various neurodegenerative and amyloid-associated diseases, as NABi would regulate aggregation of other toxic beta-sheet proteins other than A beta. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject | INTRACELLULAR AMYLOID-BETA | - |
dc.subject | SUPEROXIDE-DISMUTASE | - |
dc.subject | CASCADE HYPOTHESIS | - |
dc.subject | PRECURSOR PROTEIN | - |
dc.subject | FIBRIL FORMATION | - |
dc.subject | DRUG DEVELOPMENT | - |
dc.subject | STRUCTURAL BASIS | - |
dc.subject | TURN SEQUENCE | - |
dc.subject | PRION PROTEIN | - |
dc.title | NABi, a novel beta-sheet breaker, inhibits A beta aggregation and neuronal toxicity: Therapeutic implications for Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seongman | - |
dc.identifier.doi | 10.1016/j.bbagen.2017.10.014 | - |
dc.identifier.scopusid | 2-s2.0-85032884847 | - |
dc.identifier.wosid | 000416501300007 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v.1862, no.1, pp.71 - 80 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - |
dc.citation.volume | 1862 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 71 | - |
dc.citation.endPage | 80 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject.keywordPlus | INTRACELLULAR AMYLOID-BETA | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | CASCADE HYPOTHESIS | - |
dc.subject.keywordPlus | PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | FIBRIL FORMATION | - |
dc.subject.keywordPlus | DRUG DEVELOPMENT | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | TURN SEQUENCE | - |
dc.subject.keywordPlus | PRION PROTEIN | - |
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