Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast

Authors
Choi, Kyung-MiHong, Seok-Jinvan Deursen, Jan M.Kim, SooahKim, Kyoung HeonLee, Cheol-Koo
Issue Date
1월-2018
Publisher
OXFORD UNIV PRESS INC
Keywords
Transcriptomics; Metabolomics
Citation
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v.73, no.1, pp.29 - 38
Indexed
SCIE
SSCI
SCOPUS
Journal Title
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume
73
Number
1
Start Page
29
End Page
38
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/78467
DOI
10.1093/gerona/glx024
ISSN
1079-5006
Abstract
Rapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds to nutrient availability, seemingly mimics the effects of caloric restriction (CR) on healthy life span. However, the extent of the mechanistic overlap between RM and CR remains incompletely understood. Here, we compared the impact of CR and RM on cellular metabolic status. Both regimens maintained intracellular ATP through the chronological aging process and showed enhanced mitochondrial capacity. Comparative transcriptome analysis showed that CR had a stronger impact on global gene expression than RM. We observed a like impact on the metabolome and identified distinct metabolites affected by CR and RM. CR severely reduced the level of energy storage molecules including glycogen and lipid droplets, whereas RM did not. RM boosted the production of enzymes responsible for the breakdown of glycogen and lipid droplets. Collectively, these results provide insights into the distinct energy metabolism mechanisms induced by CR and RM, suggesting that these two anti-aging regimens might extend life span through distinctive pathways.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Kyoung Heon photo

Kim, Kyoung Heon
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE