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HCFC-123의 급성 독성간질환 발생 사례에 따른 노출기준 및 법 관리 필요성 권고Recommendation of an Occupational Exposure Limit and Legal Control Following an Acute Hepatotoxicity Incident from HCFC-123

Other Titles
Recommendation of an Occupational Exposure Limit and Legal Control Following an Acute Hepatotoxicity Incident from HCFC-123
Authors
이권섭조지훈최보경이혜림변상훈
Issue Date
2018
Publisher
한국산업보건학회
Keywords
HCFC-123; liver disease; no observed adverse effect level(NOAEL); occupational exposure limits(OELs); RfCworker; risk assessment; time-weighted average(TWA)
Citation
한국산업보건학회지, v.28, no.1, pp.80 - 90
Indexed
KCI
Journal Title
한국산업보건학회지
Volume
28
Number
1
Start Page
80
End Page
90
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/79877
DOI
10.15269/JKSOEH.2018.28.1.80
ISSN
2384-132x
Abstract
Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker(RfCworker) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident. Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCFC-123 was investigated. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity RfCworker value was calculated for HCFC-123. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: An OEL for HCFC-123 of 10 ppm(62.5 ㎎/㎥), which considered the RfCworker value, 5.56 ppm, produced in dose-response assessment and the exposure level of 19.1-20.9 ppm measured as an eight-hour TWA(time-weighted average) in the incident place, is recommended. HCFC-123 is urged to be included as a chemical requiring legal management in the Occupational Safety and Health Regulations. In addition, it is recommended that a peak exposure of ACGIH be adopted in the Notice of the Ministry of Employment and Labor.
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