Crosstalk between translation and the aggresome-autophagy pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yeonkyoung | - |
dc.contributor.author | Park, Joori | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-02T21:02:37Z | - |
dc.date.available | 2021-09-02T21:02:37Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80838 | - |
dc.description.abstract | Many neurodegenerative disorders feature the presence of misfolded polypeptide-containing intracellular inclusion bodies biochemically and morphologically analogous to cellular aggresomes. However, it is largely unknown how misfolded polypeptides form aggresomes and are eventually cleared by the aggresome-macroautophagy/autophagy pathway, so-called aggrephagy. Our recent study revealed that when the ubiquitin-proteasome system is impaired, the accumulated misfolded polypeptides are selectively recognized and transported to the aggresome by a CED complex. This complex is composed of CTIF, originally identified as a specific factor for nuclear cap-binding protein complex (a heterodimer of NCBP1/CBP80 and NCBP2/CBP20)-dependent translation (CT), and its associated factors EEF1A1 and DCTN1. Aggresomal targeting of a misfolded polypeptide via the CED complex is accompanied by CTIF release from the CT complex and thereby inhibits CT efficiency. Therefore, our study provides new mechanistic insights into the crosstalk between translational inhibition and aggresome formation under the influence of a misfolded polypeptide. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | Crosstalk between translation and the aggresome-autophagy pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1080/15548627.2017.1358849 | - |
dc.identifier.scopusid | 2-s2.0-85034771497 | - |
dc.identifier.wosid | 000441263100013 | - |
dc.identifier.bibliographicCitation | AUTOPHAGY, v.14, no.6, pp.1079 - 1081 | - |
dc.relation.isPartOf | AUTOPHAGY | - |
dc.citation.title | AUTOPHAGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1079 | - |
dc.citation.endPage | 1081 | - |
dc.type.rims | ART | - |
dc.type.docType | Editorial Material | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordAuthor | aggrephagy | - |
dc.subject.keywordAuthor | aggresome | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | CTIF | - |
dc.subject.keywordAuthor | DCTN1 | - |
dc.subject.keywordAuthor | EEF1A1 | - |
dc.subject.keywordAuthor | misfolded polypeptide | - |
dc.subject.keywordAuthor | NCBP1/CBP80 | - |
dc.subject.keywordAuthor | NCBP2/CBP20 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.