Chasing as a model of psychogenic stress: characterization of physiological and behavioral responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji-Hye | - |
dc.contributor.author | Kimm, Sunwhi | - |
dc.contributor.author | Han, Jung-Soo | - |
dc.contributor.author | Choi, June-Seek | - |
dc.date.accessioned | 2021-09-02T21:04:40Z | - |
dc.date.available | 2021-09-02T21:04:40Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1025-3890 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80857 | - |
dc.description.abstract | Being chased by a predator or a dominant conspecific can induce significant stress. However, only a limited number of laboratory studies have employed chasing by itself as a stressor. In this study, we developed a novel stress paradigm in which rats were chased by a fast-moving object in an inescapable maze. In Experiment 1, defensive behaviors and stress hormone changes induced by chasing stress were measured. During the chasing stress, the chasing-stress group (n=9) froze and emitted 22-kHz ultrasonic vocalizations (USVs), but the no-chasing control group (n=10) did not. Plasma corticosterone levels significantly increased following the chasing and were comparable to those of the restraint-stress group (n=6). In Experiment 2, the long-lasting memory of the chasing event was tested after three weeks. The chasing-stress group (n=15) showed higher levels of freezing and USV than the no-chasing group (n=14) when they were presented with the tone associated with the object's chasing action. Subsequently, the rats were subjected to Pavlovian threat conditioning with a tone as a conditioned stimulus and footshock as an unconditioned stimulus. The chasing-stress group showed higher levels of freezing and USV during the conditioning session than the no-chasing group, indicating sensitized defensive reactions in a different threat situation. Taken together, the current results suggest that chasing stress can induce long-lasting memory and sensitization of defensive responses to a new aversive event as well as immediate, significant stress responses. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | PITUITARY-ADRENAL AXIS | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | ADULT MALE-RATS | - |
dc.subject | ANIMAL-MODEL | - |
dc.subject | ACTIVE-AVOIDANCE | - |
dc.subject | TRAUMATIC MEMORY | - |
dc.subject | SINGLE EXPOSURE | - |
dc.subject | FEAR | - |
dc.subject | SENSITIZATION | - |
dc.subject | HIPPOCAMPUS | - |
dc.title | Chasing as a model of psychogenic stress: characterization of physiological and behavioral responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, June-Seek | - |
dc.identifier.doi | 10.1080/10253890.2018.1455090 | - |
dc.identifier.scopusid | 2-s2.0-85044471553 | - |
dc.identifier.wosid | 000442694000005 | - |
dc.identifier.bibliographicCitation | STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, v.21, no.4, pp.323 - 332 | - |
dc.relation.isPartOf | STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | - |
dc.citation.title | STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 323 | - |
dc.citation.endPage | 332 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PITUITARY-ADRENAL AXIS | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | ADULT MALE-RATS | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.subject.keywordPlus | ACTIVE-AVOIDANCE | - |
dc.subject.keywordPlus | TRAUMATIC MEMORY | - |
dc.subject.keywordPlus | SINGLE EXPOSURE | - |
dc.subject.keywordPlus | FEAR | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordAuthor | Chasing stress | - |
dc.subject.keywordAuthor | corticosterone | - |
dc.subject.keywordAuthor | freezing | - |
dc.subject.keywordAuthor | ultrasonic vocalization | - |
dc.subject.keywordAuthor | sensitization | - |
dc.subject.keywordAuthor | defensive response | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.