Response surface modeling of reductions in uropathogenic Escherichia coli biofilms on silicone by cranberry extract, caprylic acid, and thymol
- Authors
- Kim, Hye Won; Rhee, Min Suk
- Issue Date
- 2018
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Antimicrobial mixtures; biofilm eradication; Escherichia coli; natural products; optimization modeling; uropathogenic
- Citation
- BIOFOULING, v.34, no.6, pp.710 - 717
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOFOULING
- Volume
- 34
- Number
- 6
- Start Page
- 710
- End Page
- 717
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/80882
- DOI
- 10.1080/08927014.2018.1488969
- ISSN
- 0892-7014
- Abstract
- A response surface methodology was used to build a model to predict reductions in uropathogenic Escherichia coli biofilms in response to three compounds: cranberry extract [CB] at 3.0-9.0%, and caprylic acid [CAR] and thymol [TM] at 0.01%-0.05%. The predictive model for microbial reduction had a high regression coefficient (R-2=0.9988), and the accuracy of the model was verified (R-2=0.9527). Values of CAR, TM, and the quadratic term CAR(2) were the most significant (P<0.0001) for bacterial reduction. Interactions between CB and CAR, and TM and CB, also affected bacterial reduction. The optimum conditions (a 5.8 log(10) reduction) determined by ridge analysis were 8.3% CB +0.04% CAR +0.04% TM at 37 degrees C for 1min. The model could be used to predict the most cost-efficient amounts of antimicrobial agents for anti-urinary tract infection products such as catheter lock solution and antimicrobial coatings for catheters.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.